Gene: Cdk20

Basic information

Tag Content
Uniprot ID Q9JHU3; Q5EDC2;
Entrez ID 105278
Genbank protein ID AAF89089.1; AAH31907.1; AAW82351.1;
Genbank nucleotide ID NM_053180.2
Ensembl protein ID ENSMUSP00000021939
Ensembl nucleotide ID ENSMUSG00000021483
Gene name Cyclin-dependent kinase 20
Gene symbol Cdk20
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 28817564
Functional description Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity). Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling.
Sequence
MDQYCILGRI GEGAHGIVFK AKHVETGEIV ALKKVALRRL EDGIPNQALR EIKALQEIED 60
SQYVVQLKAV FPHGAGFVLA FEFMLSDLAE VVRHAQRPLA PAQVKSYLQM LLKGVAFCHA 120
NNIVHRDLKP ANLLISASGQ LKIADFGLAR VFSPDGGRLY THQVATRWYR APELLYGARQ 180
YDQGVDLWAV GCIMGELLNG SPLFPGENDI EQLCCVLRIL GTPSPRVWPE ITELPDYNKI 240
SFKEQAPVPL EEVLPDASPQ ALDLLGQFLL YPPRQRIAAS QALLHQYFFT APLPAHPSEL 300
PIPQRPGGPA PKAHPGPPHV HDFHVDRPLE ESLLNPELIR PFIPEG 346

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologCDK20510920A6H7E6Bos taurusPredictionMore>>
1:1 orthologCDK20476355F1PPV7Canis lupus familiarisPredictionMore>>
1:1 orthologCDK20102173001A0A452EEB7Capra hircusPredictionMore>>
1:1 orthologCDK2023552Q8IZL9Homo sapiensPredictionMore>>
1:1 orthologCdk20105278Q9JHU3CPOMus musculusPublicationMore>>
1:1 orthologCDK20K7CGC1Pan troglodytesPredictionMore>>
1:1 orthologCDK20A0A5G2RB04Sus scrofaPredictionMore>>
1:1 orthologCDK20G1STR2Oryctolagus cuniculusPredictionMore>>
1:1 orthologCdk20364666Q4KM34Rattus norvegicusPredictionMore>>
1:1 orthologcdk20494112A8WIP6Danio rerioPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0004693 cyclin-dependent protein serine/threonine kinase activityIBA
GO:0005515 protein bindingIPI
GO:0005524 ATP bindingIEA

GO:Biological Process

GO ID GO Term Evidence
GO:0006468 protein phosphorylationIBA
GO:0007049 cell cycleIEA
GO:0007275 multicellular organism developmentIEA
GO:0051301 cell divisionIEA
GO:0051726 regulation of cell cycleIEA

GO:Cellular Component

GO ID GO Term Evidence
GO:0005634 nucleusIBA
GO:0005654 nucleoplasmISO
GO:0005737 cytoplasmIEA
GO:0005929 ciliumIEA

Reactome Pathway

Reactome ID Reactome Term Evidence

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0025 Alternative splicing
KW-0067 ATP-binding
KW-0131 Cell cycle
KW-0132 Cell division
KW-0966 Cell projection
KW-0969 Cilium
KW-0963 Cytoplasm
KW-0217 Developmental protein
KW-0418 Kinase
KW-0547 Nucleotide-binding
KW-0539 Nucleus
KW-1185 Reference proteome
KW-0723 Serine/threonine-protein kinase
KW-0808 Transferase

Interpro

InterPro ID InterPro Term
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

PROSITE

PROSITE ID PROSITE Term
PS00107 PROTEIN_KINASE_ATP
PS50011 PROTEIN_KINASE_DOM
PS00108 PROTEIN_KINASE_ST

Pfam

Pfam ID Pfam Term
PF00069 Pkinase