| Tag | Content |
|---|---|
| Uniprot ID | B1PBZ7 |
| Entrez ID | 798229 |
| Genbank protein ID | ACA49506.1 |
| Genbank nucleotide ID | XM_005173056.3; NM_001122600.1; |
| Ensembl protein ID | ENSDARP00000135575 |
| Ensembl nucleotide ID | ENSDARG00000103985 |
| Gene name | Protein sprouty homolog 1 |
| Gene symbol | spry1 |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MDLRGQRGHA DPGAVLSLDQ IKAIRSNNEY TEGPAVPRRP APGPPPPPRH AHKHERTHEV 60 ILVNVNNNYE PQSSLLVRPP GLSRSTSTGS SESSSSAGSE LGLLSRTPQH HRNSVRTQPK 120 SLNAPFLPPD APLKQMHADS RDSAHLYICE SCGKCKCSEC TAPRALPARL ACNGLCLCSA 180 ENVIEQGTCM CLVKGIFYHC SKDDDDVGDA CADRPCSLSH PQCCSRFLCM GLMATLFPCL 240 LCYLPAKGCV KACNSCHDRL TRPGCRCKNS NTVYCKLQSW NQTPGHTPGK PS 292 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SPRY1 | 507095 | A6QLQ1 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | SPRY1 | 10252 | O43609 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Spry1 | 24063 | Q9QXV9 | CPO | E14.5, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | SPRY1 | 461476 | H2QQ50 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | SPRY1 | 100623283 | F1RRA2 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | SPRY1 | 100357926 | G1T8D0 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Spry1 | B5DFH3 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | spry1 | 798229 | B1PBZ7 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005829 | cytosol |
| GO:0016020 | membrane |
| GO:0048513 | animal organ development |
| GO:0008285 | negative regulation of cell population proliferation |
| GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway |
| GO:0043407 | negative regulation of MAP kinase activity |
| GO:0046580 | negative regulation of Ras protein signal transduction |
| GO:0001759 | organ induction |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51227 | SPR |
| Pfam ID | Pfam Term |
|---|---|
| PF05210 | Sprouty |