| Tag | Content |
|---|---|
| Uniprot ID | G1T8D0 |
| Entrez ID | 100357926 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_017347557.1; XM_017347556.1; |
| Ensembl protein ID | ENSOCUP00000012822 |
| Ensembl nucleotide ID | ENSOCUG00000014920 |
| Gene name | Sprouty RTK signaling antagonist 1 |
| Gene symbol | SPRY1 |
| Organism | Oryctolagus cuniculus |
| NCBI taxa ID | 9986 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MDPQNQHGSG SSLVVIQQPA LDSRQRLDYE RESQPAAILS LDQIKAIRGS NEYTEGPSVV 60 KRPAPRTAPR QEKHERTHEI IPINVNNNYE HRPTSHLGHV GLANTARGPI LSRSTSTGSA 120 ASSGSNSSAS SEQGLLGRSP PSRPVPGHRS ERVIRTQPKQ LIVDDLKGSL KEDLTRHKFI 180 CEQCGKCKCG ECTAPRTLPS CLACNRQCLC SAESMVEYGT CMCLVKGIFY HCSNDDEGDS 240 YSDNPCSCSQ SHCCSRYLCM GAMSLFLPCL LCYPPAKGCL KLCRGCYDWI HRPGCRCKNS 300 NTVYCKLESC PSRGQGKPS 319 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SPRY1 | 507095 | A6QLQ1 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | SPRY1 | 10252 | O43609 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Spry1 | 24063 | Q9QXV9 | CPO | E14.5, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | SPRY1 | 461476 | H2QQ50 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | SPRY1 | 100623283 | F1RRA2 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | SPRY1 | 100357926 | G1T8D0 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Spry1 | B5DFH3 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | spry1 | 798229 | B1PBZ7 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005623 | cell |
| GO:0005829 | cytosol |
| GO:0005794 | Golgi apparatus |
| GO:0016020 | membrane |
| GO:0005654 | nucleoplasm |
| GO:0060449 | bud elongation involved in lung branching |
| GO:0000132 | establishment of mitotic spindle orientation |
| GO:0001656 | metanephros development |
| GO:0008285 | negative regulation of cell population proliferation |
| GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway |
| GO:0034260 | negative regulation of GTPase activity |
| GO:0043407 | negative regulation of MAP kinase activity |
| GO:0051387 | negative regulation of neurotrophin TRK receptor signaling pathway |
| GO:0046580 | negative regulation of Ras protein signal transduction |
| GO:0001759 | organ induction |
| GO:0001657 | ureteric bud development |
| Keyword ID | Keyword Term |
|---|---|
| KW-1185 | Reference proteome |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51227 | SPR |
| Pfam ID | Pfam Term |
|---|---|
| PF05210 | Sprouty |