| Tag | Content |
|---|---|
| Uniprot ID | Q9QXV9 |
| Entrez ID | 24063 |
| Genbank protein ID | AAH53428.1; AAD56004.1; AAH69914.1; |
| Genbank nucleotide ID | NM_001305442.1; NM_001305441.1; NM_001305440.1; NM_011896.3; |
| Ensembl protein ID | ENSMUSP00000103744; ENSMUSP00000049292; ENSMUSP00000103742; |
| Ensembl nucleotide ID | ENSMUSG00000037211 |
| Gene name | Protein sprouty homolog 1 |
| Gene symbol | Spry1 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | E14.5, E16.5 |
| Data sources | Manually collected |
| Reference | 20459789; 22674535; |
| Functional description | Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (PubMed:29501879). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (PubMed:25576668). |
| Sequence | MDSPSQHGSH TSLVVIQPPA VEGRQRLDYD RDTQPATILS LDQIKAIRGS NEYTEGPSVA 60 RRPAPRTAPR PEKQERTHEI IPANVNSSYE HRPASHPGNA RGSVLSRSTS TGSAASSGSS 120 SSVSSEQGLL GRSPPTRPIP GHRSDRVIRT QPKQLLVEDL KASLKEDPTQ HKFICEQCGK 180 CKCGECTAPR ALPSCLACDR QCLCSAESMV EYGTCMCLVK GIFYHCSNDD DGGSYSDNPC 240 SCSQSHCCSR YLCMGALSLC LPCLLCYPPA KGCLKLCRGC YDWTHRPGCR CRNSNTVYCK 300 LESCPSRAQG KLS 313 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SPRY1 | 507095 | A6QLQ1 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | SPRY1 | 10252 | O43609 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Spry1 | 24063 | Q9QXV9 | CPO | E14.5, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | SPRY1 | 461476 | H2QQ50 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | SPRY1 | 100623283 | F1RRA2 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | SPRY1 | 100357926 | G1T8D0 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Spry1 | B5DFH3 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | spry1 | 798229 | B1PBZ7 | Danio rerio | Prediction | More>> |
| Gene symbol | Significant Variants/SNPS | Methods | PubMed ID |
|---|---|---|---|
| SPRY1 | rs908822G>A | GWAS | 28232668 |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005515 | protein binding | IPI |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000132 | establishment of mitotic spindle orientation | IGI |
| GO:0001656 | metanephros development | IGI |
| GO:0001657 | ureteric bud development | IGI |
| GO:0001657 | ureteric bud development | IMP |
| GO:0001759 | organ induction | IMP |
| GO:0008285 | negative regulation of cell population proliferation | IDA |
| GO:0034260 | negative regulation of GTPase activity | IDA |
| GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway | IDA |
| GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway | IBA |
| GO:0043407 | negative regulation of MAP kinase activity | IDA |
| GO:0043407 | negative regulation of MAP kinase activity | IBA |
| GO:0046580 | negative regulation of Ras protein signal transduction | IDA |
| GO:0046580 | negative regulation of Ras protein signal transduction | IBA |
| GO:0048513 | animal organ development | IBA |
| GO:0051387 | negative regulation of neurotrophin TRK receptor signaling pathway | IDA |
| GO:0060449 | bud elongation involved in lung branching | IGI |
| GO:0060940 | epithelial to mesenchymal transition involved in cardiac fibroblast development | IEA |
| GO:0070373 | negative regulation of ERK1 and ERK2 cascade | IDA |
| GO:0070373 | negative regulation of ERK1 and ERK2 cascade | IMP |
| GO:0070373 | negative regulation of ERK1 and ERK2 cascade | IGI |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005623 | cell | IEA |
| GO:0005654 | nucleoplasm | ISO |
| GO:0005794 | Golgi apparatus | ISO |
| GO:0005829 | cytosol | ISO |
| GO:0005829 | cytosol | IBA |
| GO:0016020 | membrane | IEA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-177929 | Signaling by EGFR | IEA |
| R-MMU-182971 | EGFR downregulation | IEA |
| R-MMU-9006934 | Signaling by Receptor Tyrosine Kinases | IEA |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51227 | SPR |
| Pfam ID | Pfam Term |
|---|---|
| PF05210 | Sprouty |