| Tag | Content |
|---|---|
| Uniprot ID | D3ZCP6 |
| Entrez ID | 501584 |
| Genbank protein ID | EDL95988.1 |
| Genbank nucleotide ID | NM_001109320.1 |
| Ensembl protein ID | ENSRNOP00000043681 |
| Ensembl nucleotide ID | ENSRNOG00000007984 |
| Gene name | APC membrane recruitment protein 1 |
| Gene symbol | Amer1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MEIQQDETVQ IKRTSTSSDA QDQGAEKGAK NKTAETTEGS TSEPPLSGPG RLKKTALKLF 60 GGKKGICTLP SFFGGGRSKG SGKGSSKKGL NKSKTHDGLS ESSHGPEDVV VEETELSTPL 120 SKSPSQFPSS QSAHGALEIG SRHKTSVTEA VEKAGVEKVP SVHKPKKGLK GFLNSIRRHR 180 KSKVSGADQS GLGAKELEGT RTMSQEHVSS ISLPSSEEIF RDAIKENTKP QDAPGPKMSP 240 AREHFSLTTE KTACKNPEKL TMTCASEFMQ PKPILEASSL EEPHTSETEG KVVTGDANPP 300 NGPVGDQLSL LFGDVTSLKS FDSLTGCGDI IAEQDMDSMT DSMASGGQRA NRDGTKRSSC 360 LVTYQGGGEE MALPDDDDNE EEEEEDEEVE LEDEEEEVKD GEEDDDLEYL WASAQIYPRF 420 NMNLGYHTAI SPSHQGYMLL DPVQSYPNLG LGELLTPQSD QQESAPNSDE GYYDSTTPGF 480 EDDSGEALGL VHRDCLPRDS YSGDALYEFY EPDDSLEHSP PGDDCLYDLR GRNSEMLDPF 540 LNLEPFSSRP PGAMETEEER LVTIQKQLLY WELRREQREA QEACAREAHA REAYSRDTHT 600 RESYGKNTRA RETQALEVHS QEGRVQETKV RQEKPALEYQ MRPLGPSVMG LVPGTPGGSQ 660 TSHRGTTSAF PATSSSEPDW RDFRPLEKRF EGTCSKKDQS TCLMQLFQSD AMFEPDMQEA 720 NFGGSPRKAY PSYSPPEEPE EEEDENEGNA TVSFSQALVE FTSNGNLFTS MSYSSDSDSS 780 FTQNLPELPP MVTFDIADVE RDGEGKCEEN PEFNNDEDLT ASLEAFELGY YHKHAFNSYH 840 SRFYQGLPWG VSSLPRYLGL PGVHPRPPPA AMALNRRSRS LDNAETLELE LSSSHLAQGY 900 VESDELQDHQ EDSDEEGEEE EGEWGRDSPL SLYTEPPGVY DWPPWAHCPV PVGPGLAWLS 960 PNQLDEPFNQ SSYVQATCCV PPVAMSVPGR APGDSVSQPA RPSHLPLPMG PCYNLQSQAS 1020 QSGRARPRDV LLPVDEPSCS SISGANSLSQ AKPVGITHGI PQLPRVRPEP LQLQPNHYRA 1080 SNLDLSKERG EQGASLSTSY SSTAMNGNLA K 1111 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | AMER1 | 100054310 | F6WVP3 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | AMER1 | 139285 | Q5JTC6 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Amer1 | 72345 | Q7TS75 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | AMER1 | H2R4P7 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | AMER1 | 100512031 | A0A5K1UCI1 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Amer1 | 501584 | D3ZCP6 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | amer1 | F1RDM5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016604 | nuclear body |
| GO:0005886 | plasma membrane |
| GO:0008013 | beta-catenin binding |
| GO:1904713 | beta-catenin destruction complex binding |
| GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| GO:0060612 | adipose tissue development |
| GO:0060348 | bone development |
| GO:0001822 | kidney development |
| GO:0072161 | mesenchymal cell differentiation involved in kidney development |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| GO:1903364 | positive regulation of cellular protein catabolic process |
| GO:0031398 | positive regulation of protein ubiquitination |
| GO:0060828 | regulation of canonical Wnt signaling pathway |
| Keyword ID | Keyword Term |
|---|---|
| KW-1185 | Reference proteome |
| InterPro ID | InterPro Term |
|---|---|
| IPR019003 | AMER |
| Pfam ID | Pfam Term |
|---|---|
| PF09422 | WTX |