| Tag | Content |
|---|---|
| Uniprot ID | F1RDM5; A9JTD0; |
| Entrez ID | |
| Genbank protein ID | AAI55292.1 |
| Genbank nucleotide ID | |
| Ensembl protein ID | |
| Ensembl nucleotide ID | |
| Gene name | APC membrane recruitment protein 1 |
| Gene symbol | amer1 |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context (By similarity). |
| Sequence | MEIATRCEVG AMRGPSSDSV SHDIPQPQSP PSVKIRKTAF KFFGGRKSIC VLPSFFGGRG 60 RSQRKGSSKT GVTKSQTYDG VSRACWDDLG RSSSEVASGD FEFCSEPQKS QEDHGKSQSL 120 PRQRRGLRGL FSSIRRHRKN KNVEVEKREA LEMSSSFHAK TVPGALPSVS DRGDYHGDSQ 180 GEELVPDVPN QTTGSECELP LAATECTIDV TLVPEKRRSR VEMDKRRRAE EEGIGEDEKT 240 GRQEGLMTYH QPLSAESELD RLAEQNVDVP DGEPPVASCS SENLVFGDVS SLKSFDSLTG 300 CGDIIADQDD VSVAESSVSA DRGSRNAGKR SSCFVTYQGG GEEMATPDEI DADYLQSLWE 360 SETSNEVCYI PSDRGSDSPS LTPDQQLSSI RATSSSSPMG ITETALTPAD LLSPQSDRQE 420 SVPNSDEGYY DSTTPGMEEE SRERPHQERL PRDSYSGDAL YELFEPDDRL LSPSLPPKDA 480 HSFVGAPLQA DKSPTNPLYS LASTAIETGA METEEERLSK IQHALLCCEL QNLRSPSKNQ 540 LLFHSDCFYD DSNLPVDDSK QDLQEVINQR YPQSPPRSQA VKEGVPRIRG QVQESSLFAP 600 CADSVLNPQV IETTRPQPQS DDQGSLRPSR GCSQSQEELM VCFSQALVDF TKNTRLYRNS 660 TESLDGSESS SPFGPSLRAL PAIVTFDVVD MENEGECEQQ TDLAEEEEEL ASPYEPFEDD 720 GCYLQQDAFA ECDQRTFDAY EQSLLLSNAW GIASLPRHLS LGRPCPPVPA PLALNRRSRS 780 LDTDSLEFQT SEIYTSVTKY DSKGTAFSQS RTVDCNDMDF PRQPCRITVD SWRRGYRQNF 840 DSSNASQQEL KLPHLSQSTV RPSHLPLKNN CRSRNLPAAT RVDGEGEILF GGGDALYPCS 900 YPPMGTQWKN RPVGVTQGVP HLRSEQSADH |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | AMER1 | 100054310 | F6WVP3 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | AMER1 | 139285 | Q5JTC6 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Amer1 | 72345 | Q7TS75 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | AMER1 | H2R4P7 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | AMER1 | 100512031 | A0A5K1UCI1 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Amer1 | 501584 | D3ZCP6 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | amer1 | F1RDM5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005634 | nucleus |
| GO:0005886 | plasma membrane |
| GO:0008013 | beta-catenin binding |
| GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| GO:0030178 | negative regulation of Wnt signaling pathway |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| GO:0060828 | regulation of canonical Wnt signaling pathway |
| GO:0016055 | Wnt signaling pathway |
| InterPro ID | InterPro Term |
|---|---|
| IPR019003 | AMER |
| Pfam ID | Pfam Term |
|---|---|
| PF09422 | WTX |