| Tag | Content |
|---|---|
| Uniprot ID | F6WVP3 |
| Entrez ID | 100054310 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_005614225.1 |
| Ensembl protein ID | ENSECAP00000002834 |
| Ensembl nucleotide ID | ENSECAG00000004232 |
| Gene name | APC membrane recruitment protein 1 |
| Gene symbol | AMER1 |
| Organism | Equus caballus |
| NCBI taxa ID | 9796 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | METQKDEAAH AKGAAASVDT KDQGKEKGAK NKEAEMMKAS EPPSSGPGRL KKTAMKLFGG 60 KRGICTLPSF FGGGRSKGSG KGSSKKSLSK SKTHDSLNEA ACGPEDIVSE RTSLSLPLPE 120 SPCELPSSRS AHRALETGSR CKTSTAGATE KAGAEKAHSV PKPKKGLKGF FSSIRRHRKS 180 KVSRSEQHEP GANGPEGART RPHEHVSPAL LLPAEETLQA PRKQNAKTQD TPGPKVSSSP 240 ESSPTATDKT ACKDPEEPRA CEACASVLLQ PKPAPEATDP EEPHSPETGE KVEAGEVNPP 300 NGPAGDQLSL LFGDVTSLKS FDSLTGCGDI IAEQDMDSMT DSMASGGQRA NRDGTKRSSC 360 LVTYQGGGEE MALPDDDDEE EEEEEDVELE EEEEVKEEED YDLEYLWAST QMYPRPNLNL 420 GYYPTTSPGH HSYILLDPVR SYPGLAPGDL LTPQSDQQES APNSDEGYYD SNTPGFEDDS 480 GEALGLVRRD CLPRDSYSGD ALYEFYEPDD SLENSPPGDD CLYDLHGHSS EIFDPFLNFE 540 TFSSSRPPGA METEEERLVT IQKQLLYWEL RREQLEAQEA RETQAREAHT REAYTQEAHA 600 REAHAREAHT QDIHVREAQA PEAYAREAWA LEAQVQELQA WQEKPIMEYQ IRPLGPSVMG 660 LVAGASGASQ TSHRGTTSAF PATANSEPDW RDFRPLEKRF EGTCSKKDQS TFLMHVFQSD 720 AMFEPDMQEA NFGGSPRRAY PTYSPPEEPE DEEVEKEGNA TVSFSQALVE FTSNGNLFSS 780 ISCSSDSDSS FTQNLPELPP MVTFDIADVE RDGEGKCEEN PEFHNDDDLA ASLEAFELGY 840 YQKHAFNNYR SRFYQGLPWG VSSLPRYLGL PGMHPRPPPA AMALNRRSRS LDTAETLELE 900 LSNSHLAQGY MESDELQAQQ EDSDEEEEEE WGGDSPLSLY TEPPGTYNWP AWAPCSLPVG 960 PVPAWISHSQ LEGPSSKSPY GQAACCISPV AMSMLSIPGQ EPRAPGESRP QLARPSHLPL 1020 PVGPCYNKPQ ASLSVRARPQ DVLLPVDEPS CSSSSGGFSP SPLPQAKPVG ITHGIPQLPR 1080 VRSEPQQPRP IHYGASSLDL SKETAEQGAS LPISYSSTVI NGNLAE 1126 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | AMER1 | 100054310 | F6WVP3 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | AMER1 | 139285 | Q5JTC6 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Amer1 | 72345 | Q7TS75 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | AMER1 | H2R4P7 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | AMER1 | 100512031 | A0A5K1UCI1 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Amer1 | 501584 | D3ZCP6 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | amer1 | F1RDM5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016604 | nuclear body |
| GO:0005886 | plasma membrane |
| GO:0008013 | beta-catenin binding |
| GO:1904713 | beta-catenin destruction complex binding |
| GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| GO:0060612 | adipose tissue development |
| GO:0060348 | bone development |
| GO:0072161 | mesenchymal cell differentiation involved in kidney development |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| GO:1903364 | positive regulation of cellular protein catabolic process |
| GO:0031398 | positive regulation of protein ubiquitination |
| GO:0060828 | regulation of canonical Wnt signaling pathway |
| Keyword ID | Keyword Term |
|---|---|
| KW-1185 | Reference proteome |
| InterPro ID | InterPro Term |
|---|---|
| IPR019003 | AMER |
| Pfam ID | Pfam Term |
|---|---|
| PF09422 | WTX |