| Tag | Content |
|---|---|
| Uniprot ID | D3ZFT1 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSRNOP00000003907 |
| Ensembl nucleotide ID | ENSRNOG00000002855 |
| Gene name | Replication factor C subunit 1 |
| Gene symbol | Rfc1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MDIRKFFGVI SSGKKPVNET VKKNEKTKPS EGTVKGKKGV KEAKVNNPCK EDASRPKQHN 60 KKKRIIYDSD SESEETVQVK NAKKKSEKLP VSCKPGKISR KDPVTYISET DEDDDFLCKK 120 AASKSKENGV STNSYLGASN VKKNEENTKT KSKPLSPIKL TPTSVLDYFG TESVQRSGKK 180 MVASKKKESS QTPDDSRLND EAIAKQLQLD EDAELERQLH EDEEFARTLA LLDEEPKTKK 240 ARKDSEEGES FSPAKAELSK AAKQKSPANE HFSIGRKTYS PAKYGKGRGS EGTKQPCRSA 300 HQKEACSSLK ASSKLALMKA QEENSYKETE LLAAKRESAI EPKGEKTTPR KTKGSPTKRE 360 SVSPEDSEKK RTNYQAYRSY LNREGPKALG SKEIPKGAEN CLEGLTFVIT GVLESIEREE 420 AKSLIERYGG KVTGNVSKKT SYLVMGRDSG QSKSDKAAAL GTKILDEDGL LDLIRTMPGK 480 KSKYEIAAEA EMKKEKSKLE RTPQKNDQGK RKLSPTKREL EPKKSKLTPL KHSPRKAVKE 540 EERVCPRGLD AKEPHGSHSA SREECLLWVD KYKPTSLKNI IGQQGDQSCA NKLLRWLRNW 600 HKSSPEEKKH AAKFGKVASK DDGSSFKAAL LSGPPGVGKT TTASLVCQEL GYSYVELNAS 660 DTRSKNSLKA IVAESLNNTS IKGFYTSGAS PSVSARHALI MDEVDGMAGN EDRGGIQELI 720 GLIKHTKIPI ICMCNDRNHP KIRSLVHYCF DLRFQRPRVE QIKSAMLSIA FKEGLKIPPP 780 AMNEIILGAN QDVRQVLHNL SMWCAQSKVL TYDQAKADSQ RAKKDIRLGP FDVTRKVFAA 840 GEETAHMSLM DKSDLFFHDY SIAPLFVQEN YLHVKPVAAG GDMKKHLMLL SRAADSICDG 900 DLVDNQIRSK QNWSLLPTQA IYASVVPGEL MRGYMSQFPS FPSWLGKHSS TGKHDRTVQD 960 LSLHMSLRTY SSKRTVNMDY LSHIRDALVR PLTSQGVEGV QRVVTLMDTY YLVKEDFDNI 1020 MEVSSWGGKP STFSKLDPKV KAAFTRAYNK EAHLTPYSLQ VVKASRPSIG PALDSEYNEE 1080 SQEDATQSDE KEQDALETDA MIKQKKTRSS KPSKSEKEKE SKKGKGKNSK K 1131 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | RFC1 | 479112 | E2QW76 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | RFC1 | 102170128 | A0A452FBS8 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | RFC1 | 5981 | P35251 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Rfc1 | 19687 | Q5U4B1 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | RFC1 | A0A2I3TIE6 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | Rfc1 | D3ZFT1 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | rfc1 | 100037336 | F1Q5P6 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005663 | DNA replication factor C complex |
| GO:0031391 | Elg1 RFC-like complex |
| GO:0005730 | nucleolus |
| GO:0005654 | nucleoplasm |
| GO:0005634 | nucleus |
| GO:0032991 | protein-containing complex |
| GO:0005524 | ATP binding |
| GO:0003677 | DNA binding |
| GO:0003689 | DNA clamp loader activity |
| GO:0061860 | DNA clamp unloader activity |
| GO:0003690 | double-stranded DNA binding |
| GO:0019904 | protein domain specific binding |
| GO:0043565 | sequence-specific DNA binding |
| GO:0090618 | DNA clamp unloading |
| GO:0006281 | DNA repair |
| GO:0006260 | DNA replication |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| PROSITE ID | PROSITE Term |
|---|---|
| PS50172 | BRCT |