| Tag | Content |
|---|---|
| Uniprot ID | Q5U4B1; G3UXL4; |
| Entrez ID | 19687 |
| Genbank protein ID | AAH85173.1 |
| Genbank nucleotide ID | NM_001347357.1 |
| Ensembl protein ID | ENSMUSP00000144954 |
| Ensembl nucleotide ID | ENSMUSG00000029191 |
| Gene name | Replication factor C subunit 1 |
| Gene symbol | Rfc1 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MDIRKFFGVI SSGKKPVNET VKNEKTKASE GTVKGKKGVK EAKVNNSGKE DASKPKQHSK 60 KKRIINDSDS ESEETVQVKN AKKKSEKLSL SYKPGKVSQK DPVTYVSETD EDDDFVCKKA 120 ASKSKENGVS TNSYLGTSNV KKNEENVKTK NKPLSPIKLT PTSVLDYFGT ESVQRSGKKM 180 VTSKRKESSQ NTEDSRLNDE AIAKQLQLDE DAELERQLHE DEEFARTLAL LDEEPKIKKA 240 RKDSEEGEES FSSVQDDLSK AEKQKSPNKA ELFSTARKTY SPAKHGKGRA SEDAKQPCKS 300 AHRKEACSSP KASAKLALMK AKEESSYNET ELLAARRKES ATEPKGEKTT PKKTKVSPTK 360 RESVSPEDSE KKRTNYQAYR SYLNREGPKA LGSKEIPKGA ENCLEGLTFV ITGVLESIER 420 DEAKSLIERY GGKVTGNVSK KTNYLVMGRD SGQSKSDKAA ALGTKILDED GLLDLIRTMP 480 GKRSKYEMAA EAEMKKEKSK LERTPQKNDQ GKRKISPAKK ESESKKCKLT LLKNSPMKAV 540 KKEASTCPRG LDVKETHGNR SSNKEECLLW VDKYKPASLK NIIGQQGDQS CANKLLRWLR 600 NWHKSSPEEK KHAAKFGKLA SKDDGSSFKA ALLSGPPGVG KTTTASLVCQ ELGYSYVELN 660 ASDTRSKNSL KAVVAESLNN TSIKGFYTSG AAPSVSARHA LIMDEVDGMA GNEDRGGIQE 720 LIGLIKHTKI PIICMCNDRN HPKIRSLVHY CFDLRFQRPR VEQIKSAMLS IAFKEGLKIP 780 PPAMNEIILG ANQDVRQVLH NLSMWCAQSK ALTYDQAKAD SQRAKKDIRL GPFDVTRKVF 840 AAGEETAHMS LMDKSDLFFH DYSIAPLFVQ ENYLHVKPVA AGGDMKKHLM LLSRAADSIC 900 DGDLVDNQIR SKQNWSLLPT QAIYASVLPG ELMRGYMTQF PSFPSWLGKH SSTGKHDRIV 960 QDLSLHMSLR TYSSKRTVNM DYLSHIRDAL VRPLTSQGVE GAQHVIKLMD TYYLMKEDFE 1020 NIMEVSSWGG KPSAFSKLDP KVKAAFTRAY NKEAHLTPYS LQVVKTSRLS TGPALDSEYS 1080 EEFQEDDTQS EKEQDAVETD AMIKQKKTRS SKPSKSEREK ESKKGKGKNW KK 1132 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | RFC1 | 479112 | E2QW76 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | RFC1 | 102170128 | A0A452FBS8 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | RFC1 | 5981 | P35251 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Rfc1 | 19687 | Q5U4B1 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | RFC1 | A0A2I3TIE6 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | Rfc1 | D3ZFT1 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | rfc1 | 100037336 | F1Q5P6 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|
| GO ID | GO Term | Evidence |
|---|
| GO ID | GO Term | Evidence |
|---|
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-110312 | Translesion synthesis by REV1 | IEA |
| R-MMU-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | IEA |
| R-MMU-110314 | Recognition of DNA damage by PCNA-containing replication complex | IEA |
| R-MMU-110320 | Translesion Synthesis by POLH | IEA |
| R-MMU-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | IEA |
| R-MMU-157579 | Telomere Maintenance | IEA |
| R-MMU-1640170 | Cell Cycle | IEA |
| R-MMU-174411 | Polymerase switching on the C-strand of the telomere | IEA |
| R-MMU-174417 | Telomere C-strand (Lagging Strand) Synthesis | IEA |
| R-MMU-180786 | Extension of Telomeres | IEA |
| R-MMU-5651801 | PCNA-Dependent Long Patch Base Excision Repair | IEA |
| R-MMU-5655862 | Translesion synthesis by POLK | IEA |
| R-MMU-5656121 | Translesion synthesis by POLI | IEA |
| R-MMU-5656169 | Termination of translesion DNA synthesis | IEA |
| R-MMU-5685942 | HDR through Homologous Recombination (HRR) | IEA |
| R-MMU-5693532 | DNA Double-Strand Break Repair | IEA |
| R-MMU-5693538 | Homology Directed Repair | IEA |
| R-MMU-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) | IEA |
| R-MMU-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER | IEA |
| R-MMU-5696398 | Nucleotide Excision Repair | IEA |
| R-MMU-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) | IEA |
| R-MMU-5696400 | Dual Incision in GG-NER | IEA |
| R-MMU-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | IEA |
| R-MMU-6782135 | Dual incision in TC-NER | IEA |
| R-MMU-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | IEA |
| R-MMU-69091 | Polymerase switching | IEA |
| R-MMU-69109 | Leading Strand Synthesis | IEA |
| R-MMU-69186 | Lagging Strand Synthesis | IEA |
| R-MMU-69190 | DNA strand elongation | IEA |
| R-MMU-69239 | Synthesis of DNA | IEA |
| R-MMU-69242 | S Phase | IEA |
| R-MMU-69278 | Cell Cycle, Mitotic | IEA |
| R-MMU-69306 | DNA Replication | IEA |
| R-MMU-73884 | Base Excision Repair | IEA |
| R-MMU-73886 | Chromosome Maintenance | IEA |
| R-MMU-73893 | DNA Damage Bypass | IEA |
| R-MMU-73894 | DNA Repair | IEA |
| R-MMU-73933 | Resolution of Abasic Sites (AP sites) | IEA |
| PROSITE ID | PROSITE Term |
|---|---|
| PS50172 | BRCT |