Gene: Nodal

Basic information

Tag Content
Uniprot ID D3ZGK9
Entrez ID 294503
Genbank protein ID EDL93025.1
Genbank nucleotide ID NM_001106394.1
Ensembl protein ID ENSRNOP00000000672
Ensembl nucleotide ID ENSRNOG00000000556
Gene name Nodal growth differentiation factor
Gene symbol Nodal
Organism Rattus norvegicus
NCBI taxa ID 10116
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MSVHCLPVLL LQTCWTLLHP RVATAAALPL WTRGQPSSPS PLAYMLSLYR DPLPRADIIR 60
SLQAQDVDVT GQNWTFTFDF SFLSQEEDLV WAELRLQLLS PMDSPTKGPL TIDIFHQAKP 120
DPEQDPADCL ERVWMERITV TPSQVTFASD STVLEVTKPL SKWLKDPRAL EKQVSSQAGK 180
CWHQSHTQPV PVTSTSVLML YSNRPQEQRQ LGGATLLWEA ESSWRAQEGQ LSVERSGWGR 240
RQRRHHLPDR SQLCRRVKFQ VDFNLIGWGS WIIYPKQYNA YRCEGECPNP VGEEFHPTNH 300
AYIQSLLKRY QPHRVPSTCC APVKTKPLSM LYVDNGRVLL EHHKDMIVEE CGCL 354

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologNODAL530748E1BJ34Bos taurusPredictionMore>>
1:1 orthologNODAL489028E2RP99Canis lupus familiarisPredictionMore>>
1:1 orthologNODAL102170202A0A452DL50Capra hircusPredictionMore>>
1:1 orthologNODAL100072735F6Y3I3Equus caballusPredictionMore>>
1:1 orthologNODAL4838Q96S42Homo sapiensPredictionMore>>
1:1 orthologNodal18119P43021CLOMus musculusPublicationMore>>
1:1 orthologNODAL466100H2Q215Pan troglodytesPredictionMore>>
1:1 orthologNODALA0A287AVE0Sus scrofaPredictionMore>>
1:1 orthologNodal294503D3ZGK9Rattus norvegicusPredictionMore>>
1:1 orthologspawF1QX69Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005125 cytokine activity
GO:0008083 growth factor activity
GO:0048018 receptor ligand activity
GO:0070698 type I activin receptor binding
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0009948 anterior/posterior axis specification
GO:0009952 anterior/posterior pattern specification
GO:0048327 axial mesodermal cell fate specification
GO:0030509 BMP signaling pathway
GO:0007420 brain development
GO:0045165 cell fate commitment
GO:0016477 cell migration
GO:0042074 cell migration involved in gastrulation
GO:0007368 determination of left/right symmetry
GO:0055123 digestive system development
GO:0048546 digestive tract morphogenesis
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0035050 embryonic heart tube development
GO:0009880 embryonic pattern specification
GO:0001892 embryonic placenta development
GO:0060136 embryonic process involved in female pregnancy
GO:0007492 endoderm development
GO:0035987 endodermal cell differentiation
GO:0060802 epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification
GO:0033505 floor plate morphogenesis
GO:0048859 formation of anatomical boundary
GO:0007369 gastrulation
GO:0001702 gastrulation with mouth forming second
GO:0007507 heart development
GO:0001947 heart looping
GO:0001701 in utero embryonic development
GO:0002085 inhibition of neuroepithelial cell differentiation
GO:0060460 left lung morphogenesis
GO:0001889 liver development
GO:0030324 lung development
GO:0001893 maternal placenta development
GO:0060137 maternal process involved in parturition
GO:0048382 mesendoderm development
GO:0001707 mesoderm formation
GO:0060766 negative regulation of androgen receptor signaling pathway
GO:0010721 negative regulation of cell development
GO:0045596 negative regulation of cell differentiation
GO:1901383 negative regulation of chorionic trophoblast cell proliferation
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:1901164 negative regulation of trophoblast cell migration
GO:0007399 nervous system development
GO:0001842 neural fold formation
GO:0038092 nodal signaling pathway
GO:1900164 nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
GO:0001890 placenta development
GO:0010085 polarity specification of proximal/distal axis
GO:0032927 positive regulation of activin receptor signaling pathway
GO:0045766 positive regulation of angiogenesis
GO:0008284 positive regulation of cell population proliferation
GO:0022409 positive regulation of cell-cell adhesion
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0050679 positive regulation of epithelial cell proliferation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0060391 positive regulation of SMAD protein signal transduction
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0090009 primitive streak formation
GO:0010470 regulation of gastrulation
GO:0009966 regulation of signal transduction
GO:0060395 SMAD protein signal transduction
GO:0019827 stem cell population maintenance
GO:0048729 tissue morphogenesis
GO:0090010 transforming growth factor beta receptor signaling pathway involved in primitive streak formation
GO:0001829 trophectodermal cell differentiation
GO:0001831 trophectodermal cellular morphogenesis
GO:0001944 vasculature development

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1015 Disulfide bond
KW-0339 Growth factor
KW-1185 Reference proteome
KW-0964 Secreted
KW-0732 Signal

Interpro

InterPro ID InterPro Term
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS

PROSITE

PROSITE ID PROSITE Term
PS00250 TGF_BETA_1
PS51362 TGF_BETA_2

Pfam

Pfam ID Pfam Term
PF00019 TGF_beta