| Tag | Content |
|---|---|
| Uniprot ID | E2RP99 |
| Entrez ID | 489028 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_546146.3 |
| Ensembl protein ID | ENSCAFP00000020713 |
| Ensembl nucleotide ID | ENSCAFG00000014052 |
| Gene name | Nodal growth differentiation factor |
| Gene symbol | NODAL |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MHAPRLPLFL LHACWALLQA GAATVAPVPL RARVQPSSPA PLAYMLSLYR DPLPRADIIR 60 SLQAQDVEVD GHNWTFAFDF SFLSQVEDLV WAELRLQLSS PVALPPGVLL SIEIFHQLKP 120 DAEQDLAACQ ERLRMDLFTV PLSHVTFSSG SMVLEVTRPL SKWLKHPGEL EAQMSSMAGG 180 CPQRPPTPPV TSVLLVLYSN LSPEQRRLGG STLLWEAESS WRAREGQLSS ERRRRHRRHH 240 VPDRSQLCRK VKFQVDFNLI GWGSWIIYPK QYNAYRCEGE CPNPVGEEFH PTNHAYIQSL 300 LKRYQPHRVP STCCAPVKTK PLSMLYVDNG RVLLDHHKDM IVEECGCL 348 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | NODAL | 530748 | E1BJ34 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | NODAL | 489028 | E2RP99 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | NODAL | 102170202 | A0A452DL50 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | NODAL | 100072735 | F6Y3I3 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | NODAL | 4838 | Q96S42 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Nodal | 18119 | P43021 | CLO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | NODAL | 466100 | H2Q215 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | NODAL | A0A287AVE0 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Nodal | 294503 | D3ZGK9 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | spaw | F1QX69 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005615 | extracellular space |
| GO:0005125 | cytokine activity |
| GO:0008083 | growth factor activity |
| GO:0070698 | type I activin receptor binding |
| GO:0048327 | axial mesodermal cell fate specification |
| GO:0030509 | BMP signaling pathway |
| GO:0007420 | brain development |
| GO:0042074 | cell migration involved in gastrulation |
| GO:0048546 | digestive tract morphogenesis |
| GO:0048701 | embryonic cranial skeleton morphogenesis |
| GO:0009880 | embryonic pattern specification |
| GO:0001892 | embryonic placenta development |
| GO:0060136 | embryonic process involved in female pregnancy |
| GO:0035987 | endodermal cell differentiation |
| GO:0060802 | epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification |
| GO:0033505 | floor plate morphogenesis |
| GO:0048859 | formation of anatomical boundary |
| GO:0001947 | heart looping |
| GO:0002085 | inhibition of neuroepithelial cell differentiation |
| GO:0060460 | left lung morphogenesis |
| GO:0001889 | liver development |
| GO:0001893 | maternal placenta development |
| GO:0060137 | maternal process involved in parturition |
| GO:0048382 | mesendoderm development |
| GO:0060766 | negative regulation of androgen receptor signaling pathway |
| GO:0010721 | negative regulation of cell development |
| GO:1901383 | negative regulation of chorionic trophoblast cell proliferation |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:1901164 | negative regulation of trophoblast cell migration |
| GO:0001842 | neural fold formation |
| GO:1900164 | nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry |
| GO:0010085 | polarity specification of proximal/distal axis |
| GO:0032927 | positive regulation of activin receptor signaling pathway |
| GO:0045766 | positive regulation of angiogenesis |
| GO:0022409 | positive regulation of cell-cell adhesion |
| GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| GO:0050679 | positive regulation of epithelial cell proliferation |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation |
| GO:0060391 | positive regulation of SMAD protein signal transduction |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0010575 | positive regulation of vascular endothelial growth factor production |
| GO:0010470 | regulation of gastrulation |
| GO:0060395 | SMAD protein signal transduction |
| GO:0019827 | stem cell population maintenance |
| GO:0090010 | transforming growth factor beta receptor signaling pathway involved in primitive streak formation |
| GO:0001831 | trophectodermal cellular morphogenesis |
| GO:0001944 | vasculature development |
| Pfam ID | Pfam Term |
|---|---|
| PF00019 | TGF_beta |