| Tag | Content |
|---|---|
| Uniprot ID | F1QX69 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSDARP00000113959 |
| Ensembl nucleotide ID | ENSDARG00000014309 |
| Gene name | Southpaw |
| Gene symbol | spaw |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | XQTSPFAMQP VIACASFALF VLRVVDCVWI DKNGAFIKDH RTAFFGAYSS QFYPRYPLYM 60 MQLYRDFSGN KMLTTPASVD NPALHQSDFV LSLIAQDCHQ TEERWTVSFD MSSLSASDNI 120 QLSELRIRLP AFSASRRVTV DIFHQHKQHC ASDSVFCRNK KLFLGSVKSV DVSQSSSSWR 180 VFNITELLQQ WLIQGMDTPD RVTAPDYDQG SGSGSGDDFI ESLTSSWPRK IQHPTAERVM 240 IVVFYKETVT HSASSLMNTV AQSKYVTLNR PADGTQGRRH KRNRVERMRM TDDRNVTGKP 300 TPSEEQQASL CRRVDMWVDF DQIGWDEWIV HPKRYNAYRC EGECPSPLDE TYNPTNHAYM 360 QSLLKLYQPE RVSCPSCVPL RLSSLSMLYY EGDGVVMRHH EDMIVEECGC H 411 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | NODAL | 530748 | E1BJ34 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | NODAL | 489028 | E2RP99 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | NODAL | 102170202 | A0A452DL50 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | NODAL | 100072735 | F6Y3I3 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | NODAL | 4838 | Q96S42 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Nodal | 18119 | P43021 | CLO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | NODAL | 466100 | H2Q215 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | NODAL | A0A287AVE0 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Nodal | 294503 | D3ZGK9 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | spaw | F1QX69 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005615 | extracellular space |
| GO:0005125 | cytokine activity |
| GO:0008083 | growth factor activity |
| GO:0070698 | type I activin receptor binding |
| GO:0030509 | BMP signaling pathway |
| GO:0071907 | determination of digestive tract left/right asymmetry |
| GO:0061371 | determination of heart left/right asymmetry |
| GO:0035462 | determination of left/right asymmetry in diencephalon |
| GO:0003140 | determination of left/right asymmetry in lateral mesoderm |
| GO:0007368 | determination of left/right symmetry |
| GO:0071910 | determination of liver left/right asymmetry |
| GO:0035469 | determination of pancreatic left/right asymmetry |
| GO:0035050 | embryonic heart tube development |
| GO:0061966 | establishment of left/right asymmetry |
| GO:0003146 | heart jogging |
| GO:0001947 | heart looping |
| GO:0048368 | lateral mesoderm development |
| GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation |
| GO:2000223 | regulation of BMP signaling pathway involved in heart jogging |
| GO:0060395 | SMAD protein signal transduction |