Gene: Nodal

Basic information

Tag Content
Uniprot ID P43021; Q8BH87;
Entrez ID 18119
Genbank protein ID EDL32144.1; BAC33661.1; BAC38637.1; CAA49914.1;
Genbank nucleotide ID NM_013611.5
Ensembl protein ID ENSMUSP00000039653
Ensembl nucleotide ID ENSMUSG00000037171
Gene name Nodal
Gene symbol Nodal
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CLO
Developmental stage
Data sources Manually collected
Reference 16564040
Functional description Essential for mesoderm formation and axial patterning during embryonic development.
Sequence
MSAHSLRILL LQACWALLHP RAPTAAALPL WTRGQPSSPS PLAYMLSLYR DPLPRADIIR 60
SLQAQDVDVT GQNWTFTFDF SFLSQEEDLV WAELRLQLPG PMDIPTEGPL TIDIFHQAKG 120
DPERDPADCL ERIWMETFTV IPSQVTFASG STVLEVTKPL SKWLKDPRAL EKQVSSRAEK 180
CWHQPYTPPV PVASTNVLML YSNRPQEQRQ LGGATLLWEA ESSWRAQEGQ LSVERGGWGR 240
RQRRHHLPDR SQLCRRVKFQ VDFNLIGWGS WIIYPKQYNA YRCEGECPNP VGEEFHPTNH 300
AYIQSLLKRY QPHRVPSTCC APVKTKPLSM LYVDNGRVLL EHHKDMIVEE CGCL 354

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Protein disorder visualization from D2P2 is currently unavailable.

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologNODAL530748E1BJ34Bos taurusPredictionMore>>
1:1 orthologNODAL489028E2RP99Canis lupus familiarisPredictionMore>>
1:1 orthologNODAL102170202A0A452DL50Capra hircusPredictionMore>>
1:1 orthologNODAL100072735F6Y3I3Equus caballusPredictionMore>>
1:1 orthologNODAL4838Q96S42Homo sapiensPredictionMore>>
1:1 orthologNodal18119P43021CLOMus musculusPublicationMore>>
1:1 orthologNODAL466100H2Q215Pan troglodytesPredictionMore>>
1:1 orthologNODALA0A287AVE0Sus scrofaPredictionMore>>
1:1 orthologNodal294503D3ZGK9Rattus norvegicusPredictionMore>>
1:1 orthologspawF1QX69Danio rerioPredictionMore>>

Other genetic variants/mutations

loading...

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0005125 cytokine activityIBA
GO:0005515 protein bindingIPI
GO:0008083 growth factor activityIEA
GO:0048018 receptor ligand activityIDA
GO:0070698 type I activin receptor bindingISO
GO:0070698 type I activin receptor bindingIBA

GO:Biological Process

GO ID GO Term Evidence
GO:0000122 negative regulation of transcription by RNA polymerase IIIDA
GO:0001701 in utero embryonic developmentIMP
GO:0001702 gastrulation with mouth forming secondIMP
GO:0001707 mesoderm formationIMP
GO:0001707 mesoderm formationTAS
GO:0001829 trophectodermal cell differentiationIDA
GO:0001831 trophectodermal cellular morphogenesisIMP
GO:0001842 neural fold formationIMP
GO:0001889 liver developmentIMP
GO:0001890 placenta developmentISO
GO:0001892 embryonic placenta developmentIMP
GO:0001893 maternal placenta developmentIMP
GO:0001944 vasculature developmentIMP
GO:0001947 heart loopingIGI
GO:0002085 inhibition of neuroepithelial cell differentiationIMP
GO:0007179 transforming growth factor beta receptor signaling pathwayISA
GO:0007368 determination of left/right symmetryIMP
GO:0007368 determination of left/right symmetryIDA
GO:0007368 determination of left/right symmetryIGI
GO:0007368 determination of left/right symmetryTAS
GO:0007369 gastrulationIMP
GO:0007399 nervous system developmentIMP
GO:0007420 brain developmentIMP
GO:0007492 endoderm developmentIMP
GO:0007507 heart developmentIMP
GO:0008284 positive regulation of cell population proliferationIMP
GO:0009880 embryonic pattern specificationIMP
GO:0009948 anterior/posterior axis specificationIMP
GO:0009952 anterior/posterior pattern specificationIMP
GO:0009952 anterior/posterior pattern specificationIGI
GO:0009966 regulation of signal transductionIDA
GO:0010085 polarity specification of proximal/distal axisIMP
GO:0010470 regulation of gastrulationIGI
GO:0010575 positive regulation of vascular endothelial growth factor productionISO
GO:0010721 negative regulation of cell developmentIMP
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylationISO
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylationIBA
GO:0016477 cell migrationIMP
GO:0019827 stem cell population maintenanceIGI
GO:0019827 stem cell population maintenanceIMP
GO:0022409 positive regulation of cell-cell adhesionISO
GO:0030324 lung developmentIMP
GO:0030509 BMP signaling pathwayIBA
GO:0032927 positive regulation of activin receptor signaling pathwayISO
GO:0033505 floor plate morphogenesisIMP
GO:0035050 embryonic heart tube developmentIMP
GO:0035987 endodermal cell differentiationISO
GO:0038092 nodal signaling pathwayIMP
GO:0042074 cell migration involved in gastrulationIDA
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic processISO
GO:0045165 cell fate commitmentIMP
GO:0045596 negative regulation of cell differentiationIDA
GO:0045766 positive regulation of angiogenesisISO
GO:0045766 positive regulation of angiogenesisIMP
GO:0045944 positive regulation of transcription by RNA polymerase IIIDA
GO:0045944 positive regulation of transcription by RNA polymerase IIIGI
GO:0048327 axial mesodermal cell fate specificationIMP
GO:0048382 mesendoderm developmentISO
GO:0048382 mesendoderm developmentIMP
GO:0048546 digestive tract morphogenesisIMP
GO:0048646 anatomical structure formation involved in morphogenesisIMP
GO:0048701 embryonic cranial skeleton morphogenesisIMP
GO:0048729 tissue morphogenesisIMP
GO:0048859 formation of anatomical boundaryIMP
GO:0050679 positive regulation of epithelial cell proliferationISO
GO:0051091 positive regulation of DNA-binding transcription factor activityISO
GO:0055123 digestive system developmentIMP
GO:0060136 embryonic process involved in female pregnancyIMP
GO:0060137 maternal process involved in parturitionIMP
GO:0060391 positive regulation of SMAD protein signal transductionISO
GO:0060395 SMAD protein signal transductionIBA
GO:0060395 SMAD protein signal transductionIDA
GO:0060460 left lung morphogenesisIMP
GO:0060766 negative regulation of androgen receptor signaling pathwayISO
GO:0060802 epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specificationIMP
GO:0070374 positive regulation of ERK1 and ERK2 cascadeISO
GO:0090009 primitive streak formationIGI
GO:0090010 transforming growth factor beta receptor signaling pathway involved in primitive streak formationIMP
GO:1900164 nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetryIMP
GO:1901164 negative regulation of trophoblast cell migrationISO
GO:1901383 negative regulation of chorionic trophoblast cell proliferationISO

GO:Cellular Component

GO ID GO Term Evidence
GO:0005576 extracellular regionIDA
GO:0005576 extracellular regionTAS
GO:0005615 extracellular spaceISO
GO:0005615 extracellular spaceIBA
GO:0005615 extracellular spaceTAS

Reactome Pathway

Reactome ID Reactome Term Evidence

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0165 Cleavage on pair of basic residues
KW-0202 Cytokine
KW-0217 Developmental protein
KW-1015 Disulfide bond
KW-0325 Glycoprotein
KW-0339 Growth factor
KW-1185 Reference proteome
KW-0964 Secreted
KW-0732 Signal

Interpro

InterPro ID InterPro Term
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS

PROSITE

PROSITE ID PROSITE Term
PS00250 TGF_BETA_1
PS51362 TGF_BETA_2

Pfam

Pfam ID Pfam Term
PF00019 TGF_beta

Protein-protein interaction

Protein-miRNA interaction