Gene: Hoxa3

Basic information

Tag Content
Uniprot ID D3ZM81
Entrez ID 108348320
Genbank protein ID EDL88160.1
Genbank nucleotide ID XM_008773712.2; XM_006236526.3; XM_006224929.2; XM_006257707.2; XM_006224928.3; XM_008762939.2; XM_006236527.2; XM_008775738.2; XM_006257706.3;
Ensembl protein ID ENSRNOP00000008447; ENSRNOP00000072327;
Ensembl nucleotide ID ENSRNOG00000061608; ENSRNOG00000006281;
Gene name Homeobox protein Hox-A3
Gene symbol Hoxa3
Organism Rattus norvegicus
NCBI taxa ID 10116
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MQKATYYDSS AIYGGYPYQA ANGFAYNASQ QPYAPSATLG TDGVEYHRPA CSLQSPASAG 60
AHPKSHELSE ACLRTLSGPP SQPPGLGDPP LPPPPPQAAP PAPQPPQPPP QPPAPTPAAP 120
PPPSSVSPPQ SANSNPTPAS TAKSPLLNSP TVGKQIFPWM KESRQNTKQK TSGSSSGESC 180
AGDKSPPGQA SSKRARTAYT SAQLVELEKE FHFNRYLCRP RRVEMANLLN LTERQIKIWF 240
QNRRMKYKKD QKGKGMLTSS GGQSPSRSPV PPGAGGYLNS MHSLVNSVPY EPQSPPPFSK 300
PPQGAYGLPP ASYPAPLPSC APPPPPQKRY TAAGSGAGGT PEYDPHAHGL QGNGSYGTPH 360
LQGSPVFVGG SYVEPMGNSG PALFGLTHLP HTTSAAVDYG GSGPLGSGHH HGPGPGEPHP 420
TYTDLTAHHP SQGRIQEAPK LTHL 444

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologHOXA3509991Q08DG7Bos taurusPredictionMore>>
1:1 orthologHOXA3482368J9NWE8Canis lupus familiarisPredictionMore>>
1:1 orthologHOXA3A0A452EKL1Capra hircusPredictionMore>>
1:1 orthologHOXA33200O43365Homo sapiensPredictionMore>>
1:1 orthologHoxa315400P02831CPOMus musculusPublicationMore>>
1:1 orthologHOXA3100519809F1SHT1Sus scrofaPredictionMore>>
1:1 orthologHoxa3108348320D3ZM81Rattus norvegicusPredictionMore>>
1:1 orthologhoxa3a58049Q8AWZ2Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005634 nucleus
GO:0003700 DNA-binding transcription factor activity
GO:0071837 HMG box domain binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001525 angiogenesis
GO:0048645 animal organ formation
GO:0009887 animal organ morphogenesis
GO:0009952 anterior/posterior pattern specification
GO:0001974 blood vessel remodeling
GO:0051216 cartilage development
GO:0048706 embryonic skeletal system development
GO:0048704 embryonic skeletal system morphogenesis
GO:0010467 gene expression
GO:0021615 glossopharyngeal nerve morphogenesis
GO:0060017 parathyroid gland development
GO:0008284 positive regulation of cell population proliferation
GO:1900122 positive regulation of receptor binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0010159 specification of animal organ position
GO:0048538 thymus development
GO:0030878 thyroid gland development

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0217 Developmental protein
KW-0238 DNA-binding
KW-0371 Homeobox
KW-0539 Nucleus
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR025281 DUF4074
IPR009057 Homeobox-like_sf
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa

PROSITE

PROSITE ID PROSITE Term
PS00032 ANTENNAPEDIA
PS00027 HOMEOBOX_1
PS50071 HOMEOBOX_2

Pfam

Pfam ID Pfam Term
PF13293 DUF4074
PF00046 Homeodomain