| Tag | Content |
|---|---|
| Uniprot ID | Q08DG7 |
| Entrez ID | 509991 |
| Genbank protein ID | AAI23760.1 |
| Genbank nucleotide ID | NM_001076825.1 |
| Ensembl protein ID | ENSBTAP00000010700; ENSBTAP00000072905; ENSBTAP00000065502; |
| Ensembl nucleotide ID | ENSBTAG00000008139 |
| Gene name | Homeobox protein Hox-A3 |
| Gene symbol | HOXA3 |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
| Sequence | MQKATYYDSS AIYGGYPYQA ANGFGYNANQ QPYPASTALG ADGEYHRPAC SLQSPANAGS 60 HPKAHELSEA CLRTLSGPPS QPPVLGEPPL APPPPQAAPP APPQPPAPPQ PPAPTPAAPP 120 PPSSVSPPQN GSSNPTPASA AKSPLLNSPT VAKQIFPWMK ESRQNTKQKT SGSSSGESCA 180 GDKSPPGQAS SKRARTAYTS AQLVELEKEF HFNRYLCRPR RVEMANLLNL TERQIKIWFQ 240 NRRMKYKKDQ KGKGMLTSSG GQSPSRSPVP PGPGSYLNSM HSLVNSVPYE PQSPPPFSKP 300 PQGAYGLPPA SYPAPLPSCA PPPPQKRYTA AGAGAGGTPD YDPHAHGLQG NGSYGTPHLQ 360 GSPVFVGGSY VEPMSNSGPP LFGLTHLPHT ASAAMDYGGA GPLGSGHHHG PGPGEPHPTY 420 TDLTAHHPSQ GRIQEAPKLT HL 442 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | HOXA3 | 509991 | Q08DG7 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | HOXA3 | 482368 | J9NWE8 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | HOXA3 | A0A452EKL1 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | HOXA3 | 3200 | O43365 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Hoxa3 | 15400 | P02831 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | HOXA3 | 100519809 | F1SHT1 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Hoxa3 | 108348320 | D3ZM81 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | hoxa3a | 58049 | Q8AWZ2 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005654 | nucleoplasm |
| GO:0005634 | nucleus |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0071837 | HMG box domain binding |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0001525 | angiogenesis |
| GO:0048645 | animal organ formation |
| GO:0009952 | anterior/posterior pattern specification |
| GO:0001974 | blood vessel remodeling |
| GO:0051216 | cartilage development |
| GO:0048704 | embryonic skeletal system morphogenesis |
| GO:0010467 | gene expression |
| GO:0021615 | glossopharyngeal nerve morphogenesis |
| GO:0060017 | parathyroid gland development |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:1900122 | positive regulation of receptor binding |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0010159 | specification of animal organ position |
| GO:0048538 | thymus development |
| GO:0030878 | thyroid gland development |