| Tag | Content |
|---|---|
| Uniprot ID | P02831; Q4V9Z8; Q61197; |
| Entrez ID | 15400 |
| Genbank protein ID | AAA37822.1; CAA72404.1; AAH96612.1; AAC52778.1; |
| Genbank nucleotide ID | NM_010452.3; XM_017321402.1; XM_011241225.2; XM_017321404.1; XM_017321403.1; |
| Ensembl protein ID | ENSMUSP00000110077 |
| Ensembl nucleotide ID | ENSMUSG00000079560 |
| Gene name | Homeobox protein Hox-A3 |
| Gene symbol | Hoxa3 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 1673020 |
| Functional description | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds 5' to its own homeobox. |
| Sequence | MQKATYYDSS AIYGGYPYQA ANGFAYNASQ QPYAPSAALG TDGVEYHRPA CSLQSPASAG 60 GHPKTHELSE ACLRTLSGPP SQPPGLGEPP LPPPPPQAAP PAPQPPQPPP QPPAPTPAAP 120 PPPSSVSPPQ SANSNPTPAS TAKSPLLNSP TVGKQIFPWM KESRQNTKQK TSGSSSGESC 180 AGDKSPPGQA SSKRARTAYT SAQLVELEKE FHFNRYLCRP RRVEMANLLN LTERQIKIWF 240 QNRRMKYKKD QKGKGMLTSS GGQSPSRSPV PPGAGGYLNS MHSLVNSVPY EPQSPPPFSK 300 PPQGAYGLPP ASYPAPLPSC APPPPPQKRY TAAGSGAGGT PDYDPHAHGL QGNGSYGTPH 360 LQGSPVFVGG SYVEPMSNSG PLFGLTHLPH TTSAAMDYGG TGPLGSGHHH GPGPGEPHPT 420 YTDLTAHHPS QGRIQEAPKL THL 443 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | HOXA3 | 509991 | Q08DG7 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | HOXA3 | 482368 | J9NWE8 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | HOXA3 | A0A452EKL1 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | HOXA3 | 3200 | O43365 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Hoxa3 | 15400 | P02831 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | HOXA3 | 100519809 | F1SHT1 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Hoxa3 | 108348320 | D3ZM81 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | hoxa3a | 58049 | Q8AWZ2 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | IBA |
| GO:0003700 | DNA-binding transcription factor activity | IDA |
| GO:0003700 | DNA-binding transcription factor activity | IBA |
| GO:0071837 | HMG box domain binding | IPI |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001525 | angiogenesis | IEA |
| GO:0001974 | blood vessel remodeling | IMP |
| GO:0008284 | positive regulation of cell population proliferation | IMP |
| GO:0009887 | animal organ morphogenesis | IMP |
| GO:0009952 | anterior/posterior pattern specification | IBA |
| GO:0009952 | anterior/posterior pattern specification | IGI |
| GO:0010159 | specification of animal organ position | IGI |
| GO:0010467 | gene expression | IMP |
| GO:0010467 | gene expression | TAS |
| GO:0021615 | glossopharyngeal nerve morphogenesis | IGI |
| GO:0021615 | glossopharyngeal nerve morphogenesis | IMP |
| GO:0030878 | thyroid gland development | IMP |
| GO:0030878 | thyroid gland development | IGI |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IBA |
| GO:0048538 | thymus development | IGI |
| GO:0048538 | thymus development | TAS |
| GO:0048538 | thymus development | IMP |
| GO:0048645 | animal organ formation | IMP |
| GO:0048704 | embryonic skeletal system morphogenesis | IBA |
| GO:0048704 | embryonic skeletal system morphogenesis | IGI |
| GO:0048706 | embryonic skeletal system development | IGI |
| GO:0051216 | cartilage development | IGI |
| GO:0060017 | parathyroid gland development | IGI |
| GO:0060017 | parathyroid gland development | TAS |
| GO:1900122 | positive regulation of receptor binding | IMP |
| GO:1900122 | positive regulation of receptor binding | TAS |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005634 | nucleus | IBA |
| GO:0005654 | nucleoplasm | ISO |
| GO:0005654 | nucleoplasm | TAS |
| Reactome ID | Reactome Term | Evidence |
|---|