Gene: Midn

Basic information

Tag Content
Uniprot ID D4AE48
Entrez ID 314623
Genbank protein ID
Genbank nucleotide ID XM_006240911.3; NM_001191577.1; XM_006240912.3;
Ensembl protein ID ENSRNOP00000057429
Ensembl nucleotide ID ENSRNOG00000015434
Gene name Midnolin
Gene symbol Midn
Organism Rattus norvegicus
NCBI taxa ID 10116
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4 (By similarity). Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion (PubMed:24187134).
Sequence
MEPQPGGARS CRRGAPGGAC ELSTTAESAA PMSLAIHSTT GTRYDLSVPH DETVEGLRKR 60
LSQRLKVPKE RLALLHKDTR LSSGKLQEFG VGDGSKLTLV PTVEAGLMSQ ASRPEQSVMQ 120
ALESLTETQP PATPGPGRAA GGGFRKYRLI LFKRPWHRQG PQSPERGGER PQVSDFLSGR 180
SPLTLALRVG DHMMFVQLQL AAQHAPLQHR HVLAAAAAAA AAARGDSSIA TPVSSPCRPV 240
SSAARVPPVS SSPSSPVSPS PVTAGTFQSH AASTTCPEQT DCSPPASSNT TSTPGSSPTP 300
RSRKPGAVIE SFVNHAPGVF SGTFSGTLHP NCQDSSGRPR RDIGTILQIL NDLLSATRHY 360
QGMPASLTQL RCHAQCSPAS PAPDLTPKTT SCEKLATPSL LQGQSQIRMC KPPGDRLRQT 420
ENRATRCKVE RLQLLLQQKR LRRKARRDAR GPYHWTPSRK AGRSDSSSSG GGGSPSEATG 480
LGLDFEDSVW KPEVNPDIQS EFVVA 505

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologMIDN102189030A0A452EXT3Capra hircusPredictionMore>>
1:1 orthologMIDN90007Q504T8Homo sapiensPredictionMore>>
1:1 orthologMidn59090Q3TPJ7CPOMus musculusPublicationMore>>
1:1 orthologMIDN749952A0A2J8J273Pan troglodytesPredictionMore>>
1:1 orthologMIDNA0A287ABE3Sus scrofaPredictionMore>>
1:1 orthologMidn314623D4AE48Rattus norvegicusPredictionMore>>
1:1 orthologmidn323713Q6NYU6Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005730 nucleolus
GO:0005634 nucleus
GO:0019900 kinase binding
GO:0033132 negative regulation of glucokinase activity
GO:0046676 negative regulation of insulin secretion

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0963 Cytoplasm
KW-0539 Nucleus
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR039336 Midnolin
IPR000626 Ubiquitin-like_dom
IPR029071 Ubiquitin-like_domsf

PROSITE

PROSITE ID PROSITE Term
PS50053 UBIQUITIN_2

Pfam

Pfam ID Pfam Term
PF00240 ubiquitin