Gene: midn

Basic information

Tag Content
Uniprot ID Q6NYU6
Entrez ID 323713
Genbank protein ID AAH66456.1; CAK04988.1;
Genbank nucleotide ID NM_207052.1
Ensembl protein ID ENSDARP00000022102; ENSDARP00000140760;
Ensembl nucleotide ID ENSDARG00000018524
Gene name Midnolin
Gene symbol midn
Organism Danio rerio
NCBI taxa ID 7955
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion.
Sequence
MDQHPSARSC SSRGAAPSCE SVSGEPPMNL YIHSTTGTRF ELSLPAEETV EGLKRRLSQR 60
LKVPKERLAL LHKETRLSSG KLQDLGITDG SKLTLVPTVE AGLMSQASRP EQSVMQALES 120
LTETQVSDFL SGRSPLTLAL RVGDHMMFVQ LQLAAQPSGG PQLQHRHLIS RGSSEGTTGL 180
SHGASGSASG MARVSHNPHP HHPHQHPHHP NTTLPSNPAA FPPSPSIPSI PPMYSTSASG 240
HCSPPPQPSQ LPGSFLHSQQ PSSACAPSPS SPSPAASCPE ASCSAKTSGN CNTPLRSRKP 300
GAIIESFVNH APGVFSGTFS GTLHPNCQDS TGRPRRDIGT ILQILNDLLS ATRHYQGMPP 360
SLTQLRYQTQ CTSPNSPAPS PPPSPPHTTG LTGLPTTVPS ETQPTLHPLV QCQSQIRMCK 420
PPGDRLRQTE NRATRCKVER LQLLMQQKRL RRKARRDSRA PYHWLPNRKA GRSNSNSSMS 480
SEGSLDLDFE DSVWKPDVKA DMKSEFIMA 509

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologMIDN102189030A0A452EXT3Capra hircusPredictionMore>>
1:1 orthologMIDN90007Q504T8Homo sapiensPredictionMore>>
1:1 orthologMidn59090Q3TPJ7CPOMus musculusPublicationMore>>
1:1 orthologMIDN749952A0A2J8J273Pan troglodytesPredictionMore>>
1:1 orthologMIDNA0A287ABE3Sus scrofaPredictionMore>>
1:1 orthologMidn314623D4AE48Rattus norvegicusPredictionMore>>
1:1 orthologmidn323713Q6NYU6Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005829 cytosol
GO:0005730 nucleolus
GO:0005634 nucleus

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0963 Cytoplasm
KW-0539 Nucleus
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR039336 Midnolin
IPR000626 Ubiquitin-like_dom
IPR029071 Ubiquitin-like_domsf

PROSITE

PROSITE ID PROSITE Term
PS50053 UBIQUITIN_2

Pfam

Pfam ID Pfam Term
PF00240 ubiquitin