Gene: Midn

Basic information

Tag Content
Uniprot ID Q3TPJ7; Q3U3X5; Q9JJJ6;
Entrez ID 59090
Genbank protein ID BAE32660.1; BAB00638.1; AAH34719.1; BAE37739.1;
Genbank nucleotide ID NM_021565.2; XM_017314035.1; NM_001347117.1; XM_006513913.3; NM_001305799.1; NM_001305798.1;
Ensembl protein ID ENSMUSP00000097091; ENSMUSP00000046967;
Ensembl nucleotide ID ENSMUSG00000035621
Gene name Midnolin
Gene symbol Midn
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 27933520
Functional description Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4 (PubMed:27326929). Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion (By similarity).
Sequence
MEPQPGGARS CRRGAPGGAC ELNTATESAA PMSLAIHSTT GTRYDLSVPH DETVEGLRKR 60
LSQRLKVPKE RLALLHKDTR LSSGKLQEFG VGDGSKLTLV PTVEAGLMSQ ASRPEQSVMQ 120
ALESLTETQV SDFLSGRSPL TLALRVGDHM MFVQLQLAAQ HAPLQHRHVL AAAAAAAAAA 180
RGDSSVATPV SSPCRPVSSA ARVPPVSSSP SSPVSPSPVT AGSFRSHAAS TTCPEQMDCS 240
PPASSSSTST PGSSPTPRSR KPGAVIESFV NHAPGVFSGT FSGTLHPNCQ DSSGRPRRDI 300
GTILQILNDL LSATRHYQGM PPSLTQLRCH AQCSPASPAP DLTPKTTSCE KLAATSSTSL 360
LQGQSQIRMC KPPGDRLRQT ENRATRCKVE RLQLLLQQKR LRRKARRDAR GPYHWTPSRK 420
AGRSDSSSSG GGGGPSEATG LGLDFEDSVW KPEVNPDIQS EFVVA 465

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologMIDN102189030A0A452EXT3Capra hircusPredictionMore>>
1:1 orthologMIDN90007Q504T8Homo sapiensPredictionMore>>
1:1 orthologMidn59090Q3TPJ7CPOMus musculusPublicationMore>>
1:1 orthologMIDN749952A0A2J8J273Pan troglodytesPredictionMore>>
1:1 orthologMIDNA0A287ABE3Sus scrofaPredictionMore>>
1:1 orthologMidn314623D4AE48Rattus norvegicusPredictionMore>>
1:1 orthologmidn323713Q6NYU6Danio rerioPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0019900 kinase bindingISO

GO:Biological Process

GO ID GO Term Evidence
GO:0033132 negative regulation of glucokinase activityISO
GO:0046676 negative regulation of insulin secretionISO

GO:Cellular Component

GO ID GO Term Evidence
GO:0005634 nucleusISO
GO:0005634 nucleusIBA
GO:0005634 nucleusIDA
GO:0005730 nucleolusIDA
GO:0005737 cytoplasmISO
GO:0005829 cytosolIDA
GO:0005730 nucleolusISO

Reactome Pathway

Reactome ID Reactome Term Evidence

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0025 Alternative splicing
KW-0963 Cytoplasm
KW-0539 Nucleus
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR039336 Midnolin
IPR000626 Ubiquitin-like_dom
IPR029071 Ubiquitin-like_domsf

PROSITE

PROSITE ID PROSITE Term
PS50053 UBIQUITIN_2

Pfam

Pfam ID Pfam Term
PF00240 ubiquitin

Protein-miRNA interaction