Gene: BCL3

Basic information

Tag Content
Uniprot ID E1BCE6
Entrez ID 531942
Genbank protein ID
Genbank nucleotide ID NM_001205993.1
Ensembl protein ID ENSBTAP00000012490
Ensembl nucleotide ID ENSBTAG00000009493
Gene name BCL3 transcription coactivator
Gene symbol BCL3
Organism Bos taurus
NCBI taxa ID 9913
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MPRCPAGTMD EGPVDLRTRP KATGPPGAAL PLRKRPLRAP SPEPAAPRVA AGPVVPPDPL 60
RGGSDTPAVL APPHGLARPE AIYYQGPLLS LYPTPTMGPP FPLLNLPTPL YPMVCSMEHP 120
LSADFAMATR ADEDGDTPLH IAVVQGNLPA VHRLVNLFQH GGRELDIYNN LRQTPLHLAV 180
ITTLPSVVRL LVMAGASPMA LDRHGQTAAH LACEHRSPAC LRALLDSAPG GTMDLEARNY 240
DGLTALHVAV NTECQEAVLL LLEHGADIDA VDIKSGRSPL IHAVENNSLS MVQLLLQHGA 300
NVNAQMYSGS SALHSASGRG LLPLVRTLVR SGADSGLKNC HNDTPLMVAR SRRVIDILRG 360
KATRPAPASQ PEPSPDRSTT TSPESSSRLS SNGLLSASPP SSPSQSPPKD PSGFPMAPPS 420
FFLPPSSPPT FLPYAGVLRA PGRPVPPSPA PGGS 454

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologBCL3531942E1BCE6Bos taurusPredictionMore>>
1:1 orthologBCL3102188215A0A452EUS0Capra hircusPredictionMore>>
1:1 orthologBCL3602P20749CL/PHomo sapiensPublicationMore>>
1:1 orthologBcl312051Q9Z2F6Mus musculusPredictionMore>>
1:1 orthologBCL3K7DP79Pan troglodytesPredictionMore>>
1:1 orthologBcl3D3ZQF8Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0032996 Bcl3-Bcl10 complex
GO:0033257 Bcl3/NF-kappaB2 complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030496 midbody
GO:0005654 nucleoplasm
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0003700 DNA-binding transcription factor activity
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0008134 transcription factor binding
GO:0019730 antimicrobial humoral response
GO:0006974 cellular response to DNA damage stimulus
GO:0042742 defense response to bacterium
GO:0042832 defense response to protozoan
GO:0030330 DNA damage response, signal transduction by p53 class mediator
GO:0030198 extracellular matrix organization
GO:0002268 follicular dendritic cell differentiation
GO:0002467 germinal center formation
GO:0002455 humoral immune response mediated by circulating immunoglobulin
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0002315 marginal zone B cell differentiation
GO:0043066 negative regulation of apoptotic process
GO:0045415 negative regulation of interleukin-8 biosynthetic process
GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT
GO:0045892 negative regulation of transcription, DNA-templated
GO:0042536 negative regulation of tumor necrosis factor biosynthetic process
GO:0032729 positive regulation of interferon-gamma production
GO:0045082 positive regulation of interleukin-10 biosynthetic process
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045727 positive regulation of translation
GO:0042981 regulation of apoptotic process
GO:0051101 regulation of DNA binding
GO:1901222 regulation of NIK/NF-kappaB signaling
GO:0010225 response to UV-C
GO:0009615 response to virus
GO:0048536 spleen development
GO:0042088 T-helper 1 type immune response
GO:0045064 T-helper 2 cell differentiation
GO:0006351 transcription, DNA-templated

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0040 ANK repeat
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf

PROSITE

PROSITE ID PROSITE Term
PS50297 ANK_REP_REGION
PS50088 ANK_REPEAT

Pfam

Pfam ID Pfam Term
PF00023 Ank
PF12796 Ank_2