| Tag | Content |
|---|---|
| Uniprot ID | Q9Z2F6 |
| Entrez ID | 12051 |
| Genbank protein ID | AAC79694.1 |
| Genbank nucleotide ID | NM_033601.3 |
| Ensembl protein ID | ENSMUSP00000113851 |
| Ensembl nucleotide ID | ENSMUSG00000053175 |
| Gene name | B-cell lymphoma 3 protein homolog |
| Gene symbol | Bcl3 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit (By similarity). In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation. |
| Sequence | MPRCPAGAMD EGPVDLRTRP KGTPGAALPL RKRPLRPASP EPATTRSPAG PLDALRSGCD 60 VPVVPGPPHC VARPEALYYQ GPLMPIYSTP TMAPHFPLLN LPTHPYSMIC PMEHPLSADI 120 AMATRVDEDG DTPLHIAVVQ NNIAAVYRIL SLFKLGSREV DVHNNLRQTP LHLAVITTLP 180 DMVRLLVTAG ASPMALDRHG QTAIHLACEH RSPSCLQALL DSATSGSVDL EVRNYEGLTA 240 LHVAVNTGCQ EAVLLLLERG ADIDAVDIKS GRSPLIHAVE NNSLNMVQLL LLHGANVNAQ 300 MYSGSSALHS ASGRGLLPLV RTLVRSGADS GLKNCHNDTP LMVARSRRVI DILRGKASRA 360 ASGSQPEPSP DQSATNSPES SSRLSSNGLQ SSPSSSPSLS PPKDAPGFPA TPQNFFLPTT 420 STPAFLPFPG VLRGPGRPVP PSPAPGSS 448 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | BCL3 | 531942 | E1BCE6 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | BCL3 | 102188215 | A0A452EUS0 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | BCL3 | 602 | P20749 | CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Bcl3 | 12051 | Q9Z2F6 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | BCL3 | K7DP79 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | Bcl3 | D3ZQF8 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | IDA |
| GO:0003700 | DNA-binding transcription factor activity | IDA |
| GO:0005515 | protein binding | IPI |
| GO:0008134 | transcription factor binding | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0002268 | follicular dendritic cell differentiation | IMP |
| GO:0002315 | marginal zone B cell differentiation | IMP |
| GO:0002455 | humoral immune response mediated by circulating immunoglobulin | IMP |
| GO:0002467 | germinal center formation | IMP |
| GO:0006351 | transcription, DNA-templated | ISO |
| GO:0006974 | cellular response to DNA damage stimulus | ISO |
| GO:0007249 | I-kappaB kinase/NF-kappaB signaling | ISO |
| GO:0009615 | response to virus | ISO |
| GO:0010225 | response to UV-C | ISO |
| GO:0019730 | antimicrobial humoral response | IMP |
| GO:0030198 | extracellular matrix organization | IMP |
| GO:0030330 | DNA damage response, signal transduction by p53 class mediator | ISO |
| GO:0032729 | positive regulation of interferon-gamma production | IMP |
| GO:0042088 | T-helper 1 type immune response | IMP |
| GO:0042536 | negative regulation of tumor necrosis factor biosynthetic process | IMP |
| GO:0042742 | defense response to bacterium | IMP |
| GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | ISO |
| GO:0042832 | defense response to protozoan | IMP |
| GO:0042981 | regulation of apoptotic process | ISO |
| GO:0043066 | negative regulation of apoptotic process | ISO |
| GO:0043066 | negative regulation of apoptotic process | IGI |
| GO:0043066 | negative regulation of apoptotic process | IMP |
| GO:0045064 | T-helper 2 cell differentiation | IMP |
| GO:0045082 | positive regulation of interleukin-10 biosynthetic process | IMP |
| GO:0045415 | negative regulation of interleukin-8 biosynthetic process | ISO |
| GO:0045727 | positive regulation of translation | ISO |
| GO:0045892 | negative regulation of transcription, DNA-templated | ISO |
| GO:0045893 | positive regulation of transcription, DNA-templated | ISO |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IDA |
| GO:0046426 | negative regulation of receptor signaling pathway via JAK-STAT | ISO |
| GO:0048536 | spleen development | IMP |
| GO:0051101 | regulation of DNA binding | IEA |
| GO:1901222 | regulation of NIK/NF-kappaB signaling | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005634 | nucleus | ISO |
| GO:0005654 | nucleoplasm | ISO |
| GO:0005737 | cytoplasm | ISO |
| GO:0005829 | cytosol | ISO |
| GO:0005886 | plasma membrane | ISO |
| GO:0030496 | midbody | ISO |
| GO:0032991 | protein-containing complex | ISO |
| GO:0032996 | Bcl3-Bcl10 complex | ISO |
| GO:0033257 | Bcl3/NF-kappaB2 complex | ISO |
| GO:0043231 | intracellular membrane-bounded organelle | ISO |
| GO:0048471 | perinuclear region of cytoplasm | IEA |
| Reactome ID | Reactome Term | Evidence |
|---|