Gene: HOXA2

Basic information

Tag Content
Uniprot ID E2R5Y1
Entrez ID 609592
Genbank protein ID
Genbank nucleotide ID XM_846812.4
Ensembl protein ID ENSCAFP00000004363
Ensembl nucleotide ID ENSCAFG00000002942
Gene name Homeobox A2
Gene symbol HOXA2
Organism Canis lupus familiaris
NCBI taxa ID 9615
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MNYEFEREIG FINSQPSLAE CLTSFPPVAD TFQSSSIKTS TLSHSTLIPP PFEQTIPSLN 60
PGSHPRHGAG GRPKPSPAGS RGSPVPAGAL QPPEYPWMKE KKAAKKTALP PAAAAAAAAT 120
GPACLGHKES LEIADGSGGG SRRLRTAYTN TQLLELEKEF HFNKYLCRPR RVEIAALLDL 180
TERQVKVWFQ NRRMKHKRQT QCKENQNSEG KFKSLEDSEK VEEDEEEKSL FEQALSVSGA 240
LLEREGYTFQ QNALSQQQAP NGHNGDSQSF PVSPLTSNEK NLKHFQHQSP TVSNCLSTMG 300
QNCGSGLNND SPETLEVPSL QDFNVFSTDS CLQLSDAVSP SLPGSLDSPV DISADSFDFF 360
TDTLTTIDLQ HLNY 374

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologHOXA2F1MD21Bos taurusPredictionMore>>
1:1 orthologHOXA2609592E2R5Y1Canis lupus familiarisPredictionMore>>
1:1 orthologHOXA2102172597A0A452FXW8Capra hircusPredictionMore>>
1:1 orthologHOXA23199O43364Homo sapiensPredictionMore>>
1:1 orthologHoxa215399P31245CPOE12.5, E14.0, E13.5, E14.5, E15.0, E15.5Mus musculusPublicationMore>>
1:1 orthologHOXA2100519993F1SHT0Sus scrofaPredictionMore>>
1:1 orthologHoxa2108348165G3V6R6Rattus norvegicusPredictionMore>>
1:1 orthologhoxa2bB3DG99Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005654 nucleoplasm
GO:0005634 nucleus
GO:0003700 DNA-binding transcription factor activity
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0009952 anterior/posterior pattern specification
GO:0035284 brain segmentation
GO:0001709 cell fate determination
GO:0071300 cellular response to retinoic acid
GO:0009953 dorsal/ventral pattern formation
GO:0048703 embryonic viscerocranium morphogenesis
GO:0042474 middle ear morphogenesis
GO:0008045 motor neuron axon guidance
GO:0045665 negative regulation of neuron differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0002076 osteoblast development
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0021568 rhombomere 2 development
GO:0021658 rhombomere 3 morphogenesis
GO:0007379 segment specification

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0217 Developmental protein
KW-0238 DNA-binding
KW-0371 Homeobox
KW-0539 Nucleus
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR009057 Homeobox-like_sf
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa

PROSITE

PROSITE ID PROSITE Term
PS00032 ANTENNAPEDIA
PS00027 HOMEOBOX_1
PS50071 HOMEOBOX_2

Pfam

Pfam ID Pfam Term
PF00046 Homeodomain