| Tag | Content |
|---|---|
| Uniprot ID | P31245; Q149U3; Q920T8; |
| Entrez ID | 15399 |
| Genbank protein ID | AAI17108.1; AAA37835.1; BAB68715.1; AAA37834.1; AAI17106.1; AAA37827.1; AAA37836.1; |
| Genbank nucleotide ID | NM_010451.2 |
| Ensembl protein ID | ENSMUSP00000014848 |
| Ensembl nucleotide ID | ENSMUSG00000014704 |
| Gene name | Homeobox protein Hox-A2 |
| Gene symbol | Hoxa2 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | E12.5, E14.0, E13.5, E14.5, E15.0, E15.5 |
| Data sources | Manually collected |
| Reference | 10529419; 7903601; 7903600; |
| Functional description | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
| Sequence | MNYEFEREIG FINSQPSLAE CLTSFPPVAD TFQSSSIKTS TLSHSTLIPP PFEQTIPSLN 60 PGSHPRHGAG VGGRPKSSPA GSRGSPVPAG ALQPPEYPWM KEKKAAKKTA LPPAAASTGP 120 ACLGHKESLE IADGSGGGSR RLRTAYTNTQ LLELEKEFHF NKYLCRPRRV EIAALLDLTE 180 RQVKVWFQNR RMKHKRQTQC KENQNSEGKF KNLEDSDKVE EDEEEKSLFE QALSVSGALL 240 EREGYTFQQN ALSQQQAPNG HNGDSQTFPV SPLTSNEKNL KHFQHQSPTV PNCLSTMGQN 300 CGAGLNNDSP EAIEVPSLQD FNVFSTDSCL QLSDALSPSL PGSLDSPVDI SADSFDFFTD 360 TLTTIDLQHL NY 372 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | HOXA2 | F1MD21 | Bos taurus | Prediction | More>> | |||
| 1:1 ortholog | HOXA2 | 609592 | E2R5Y1 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | HOXA2 | 102172597 | A0A452FXW8 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | HOXA2 | 3199 | O43364 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Hoxa2 | 15399 | P31245 | CPO | E12.5, E14.0, E13.5, E14.5, E15.0, E15.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | HOXA2 | 100519993 | F1SHT0 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Hoxa2 | 108348165 | G3V6R6 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | hoxa2b | B3DG99 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | IDA |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | IBA |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IDA |
| GO:0003700 | DNA-binding transcription factor activity | IBA |
| GO:0043565 | sequence-specific DNA binding | IDA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IBA |
| GO:0001709 | cell fate determination | IMP |
| GO:0002076 | osteoblast development | IGI |
| GO:0007379 | segment specification | IMP |
| GO:0007389 | pattern specification process | IMP |
| GO:0008045 | motor neuron axon guidance | IMP |
| GO:0009952 | anterior/posterior pattern specification | IMP |
| GO:0009953 | dorsal/ventral pattern formation | IGI |
| GO:0009953 | dorsal/ventral pattern formation | IMP |
| GO:0021568 | rhombomere 2 development | IMP |
| GO:0021569 | rhombomere 3 development | IGI |
| GO:0021658 | rhombomere 3 morphogenesis | IMP |
| GO:0035284 | brain segmentation | IMP |
| GO:0042474 | middle ear morphogenesis | IGI |
| GO:0042474 | middle ear morphogenesis | IMP |
| GO:0045165 | cell fate commitment | IMP |
| GO:0045665 | negative regulation of neuron differentiation | IGI |
| GO:0045665 | negative regulation of neuron differentiation | IMP |
| GO:0045668 | negative regulation of osteoblast differentiation | IDA |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IDA |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IBA |
| GO:0048703 | embryonic viscerocranium morphogenesis | IMP |
| GO:0048704 | embryonic skeletal system morphogenesis | IGI |
| GO:0071300 | cellular response to retinoic acid | IDA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005634 | nucleus | IDA |
| GO:0005634 | nucleus | IBA |
| GO:0005654 | nucleoplasm | ISO |
| GO:0005654 | nucleoplasm | TAS |
| GO:0043231 | intracellular membrane-bounded organelle | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|
| Pfam ID | Pfam Term |
|---|---|
| PF00046 | Homeodomain |