| Tag | Content |
|---|---|
| Uniprot ID | F1SHT0 |
| Entrez ID | 100519993 |
| Genbank protein ID | HDB33367.1 |
| Genbank nucleotide ID | XM_003134843.4 |
| Ensembl protein ID | ENSSSCP00000017696 |
| Ensembl nucleotide ID | ENSSSCG00000016706 |
| Gene name | Homeobox A2 |
| Gene symbol | HOXA2 |
| Organism | Sus scrofa |
| NCBI taxa ID | 9823 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MNYEFEREIG FINSQPSLAE CLTSFPPVAD TFQSSSIKTS TLSHSTLIPP PFEQTIPSLN 60 PGSHPRHGAG GRPKPSPAGS RGSPVPAGAL QPPEYPWMKE KKAAKKTALP PASAAAAAAA 120 AAAAATGPAC LSHKESLEIA DGSGGGSRRL RTAYTNTQLL ELEKEFHFNK YLCRPRRVEI 180 AALLDLTERQ VKVWFQNRRM KHKRQTQCKE NQNSEGKFKS LEDSEKVEED EEEKSLFEQA 240 LSVSGALLER EGYTFQQNAL SQQQAPNGHN GDSQSFPVSP LTSNEKNLKH FQHQSPTVPN 300 CLSTMGQNCG SGLNNDSPEA LEVPSLQDFN VFSTDSCLQL SDAVSPSLPG SLDSPVDISA 360 DSFDFFTDTL TTIDLQHLNY |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | HOXA2 | F1MD21 | Bos taurus | Prediction | More>> | |||
| 1:1 ortholog | HOXA2 | 609592 | E2R5Y1 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | HOXA2 | 102172597 | A0A452FXW8 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | HOXA2 | 3199 | O43364 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Hoxa2 | 15399 | P31245 | CPO | E12.5, E14.0, E13.5, E14.5, E15.0, E15.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | HOXA2 | 100519993 | F1SHT0 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Hoxa2 | 108348165 | G3V6R6 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | hoxa2b | B3DG99 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005654 | nucleoplasm |
| GO:0005634 | nucleus |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0009952 | anterior/posterior pattern specification |
| GO:0035284 | brain segmentation |
| GO:0001709 | cell fate determination |
| GO:0071300 | cellular response to retinoic acid |
| GO:0009953 | dorsal/ventral pattern formation |
| GO:0048703 | embryonic viscerocranium morphogenesis |
| GO:0042474 | middle ear morphogenesis |
| GO:0008045 | motor neuron axon guidance |
| GO:0045665 | negative regulation of neuron differentiation |
| GO:0045668 | negative regulation of osteoblast differentiation |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0002076 | osteoblast development |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0021568 | rhombomere 2 development |
| GO:0021658 | rhombomere 3 morphogenesis |
| GO:0007379 | segment specification |
| Pfam ID | Pfam Term |
|---|---|
| PF00046 | Homeodomain |