| Tag | Content |
|---|---|
| Uniprot ID | E2RB53 |
| Entrez ID | 478575 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_535751.5 |
| Ensembl protein ID | ENSCAFP00000034412 |
| Ensembl nucleotide ID | ENSCAFG00000011122 |
| Gene name | Glycogen synthase kinase 3 beta |
| Gene symbol | GSK3B |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR PQEVSYTDTK 60 VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI MRKLDHCNIV RLRYFFYSSG 120 EKKDEVYLNL VLDYVPETVY RVARHYSRAK QTLPVIYVKL YMYQLFRSLA YIHSFGICHR 180 DIKPQNLLLD PDTAVLKLCD FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV 240 WSAGCVLAEL LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP 300 WTKDSSGTGH FTSGVRVFRP RTPPEAIALC SRLLEYTPTA RLTPLEACAH SFFDELRDPN 360 VKLPNGRDTP ALFNFTTQEL SSNPPLATIL IPPHARIQAA ASTPTNATAA SDANAGDRGQ 420 TNNAASASAS NST 433 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | GSK3B | 478575 | E2RB53 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | GSK3B1 | 102176363 | A0A097P8R4 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | GSK3B | 2932 | P49841 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Gsk3b | 56637 | Q9WV60 | CPO | E12.5, E13.5, E14.5, P6 | Mus musculus | Publication | More>> |
| 1:1 ortholog | GSK3B | 100616510 | K7CFX8 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | GSK3B | I6ZJZ7 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | GSK3B | 100348842 | A0A5F9CM08 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Gsk3b | 84027 | A0A0G2KB98 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | gsk3ba | 30654 | Q9YH60 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0030424 | axon |
| GO:0030877 | beta-catenin destruction complex |
| GO:0005813 | centrosome |
| GO:0005737 | cytoplasm |
| GO:0005829 | cytosol |
| GO:0098978 | glutamatergic synapse |
| GO:0005654 | nucleoplasm |
| GO:0005634 | nucleus |
| GO:0005886 | plasma membrane |
| GO:0005524 | ATP binding |
| GO:0008013 | beta-catenin binding |
| GO:0034452 | dynactin binding |
| GO:0051059 | NF-kappaB binding |
| GO:0002039 | p53 binding |
| GO:0002020 | protease binding |
| GO:0034236 | protein kinase A catalytic subunit binding |
| GO:0004674 | protein serine/threonine kinase activity |
| GO:0001085 | RNA polymerase II transcription factor binding |
| GO:0050321 | tau-protein kinase activity |
| GO:0031625 | ubiquitin protein ligase binding |
| GO:0001837 | epithelial to mesenchymal transition |
| GO:0006983 | ER overload response |
| GO:0097192 | extrinsic apoptotic signaling pathway in absence of ligand |
| GO:0005977 | glycogen metabolic process |
| GO:0021766 | hippocampus development |
| GO:0008286 | insulin receptor signaling pathway |
| GO:0035556 | intracellular signal transduction |
| GO:0070885 | negative regulation of calcineurin-NFAT signaling cascade |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| GO:1901215 | negative regulation of neuron death |
| GO:0032091 | negative regulation of protein binding |
| GO:0031333 | negative regulation of protein-containing complex assembly |
| GO:0031175 | neuron projection development |
| GO:0018105 | peptidyl-serine phosphorylation |
| GO:0018107 | peptidyl-threonine phosphorylation |
| GO:0001954 | positive regulation of cell-matrix adhesion |
| GO:0043547 | positive regulation of GTPase activity |
| GO:0010822 | positive regulation of mitochondrion organization |
| GO:1901216 | positive regulation of neuron death |
| GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| GO:0046827 | positive regulation of protein export from nucleus |
| GO:1904781 | positive regulation of protein localization to centrosome |
| GO:0031334 | positive regulation of protein-containing complex assembly |
| GO:0046777 | protein autophosphorylation |
| GO:0150101 | regulation of microtubule anchoring at centrosome |
| GO:0070507 | regulation of microtubule cytoskeleton organization |
| GO:0010975 | regulation of neuron projection development |
| GO:2000300 | regulation of synaptic vesicle exocytosis |
| GO:0007165 | signal transduction |
| GO:0071109 | superior temporal gyrus development |
| Pfam ID | Pfam Term |
|---|---|
| PF00069 | Pkinase |