Gene: GSK3B

Basic information

Tag Content
Uniprot ID K7CFX8; A0A2J8M3L0;
Entrez ID 100616510
Genbank protein ID JAA37002.1; JAA25043.1; JAA06006.1; JAA17817.1;
Genbank nucleotide ID XM_016941721.1
Ensembl protein ID ENSPTRP00000074940
Ensembl nucleotide ID ENSPTRG00000015264
Gene name Glycogen synthase kinase 3 beta
Gene symbol GSK3B
Organism Pan troglodytes
NCBI taxa ID 9598
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR PQEVSYTDTK 60
VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI MRKLDHCNIV RLRYFFYSSG 120
EKKDEVYLNL VLDYVPETVY RVARHYSRAK QTLPVIYVKL YMYQLFRSLA YIHSFGICHR 180
DIKPQNLLLD PDTAVLKLCD FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV 240
WSAGCVLAEL LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP 300
WTKVFRPRTP PEAIALCSRL LEYTPTARLT PLEACAHSFF DELRDPNVKL PNGRDTPALF 360
NFTTQELSSN PPLATILIPP HARIQAAAST PTNATAASDA NTGDRGQTNN AASASASNST 420

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologGSK3B478575E2RB53Canis lupus familiarisPredictionMore>>
1:1 orthologGSK3B1102176363A0A097P8R4Capra hircusPredictionMore>>
1:1 orthologGSK3B2932P49841Homo sapiensPredictionMore>>
1:1 orthologGsk3b56637Q9WV60CPOE12.5, E13.5, E14.5, P6Mus musculusPublicationMore>>
1:1 orthologGSK3B100616510K7CFX8Pan troglodytesPredictionMore>>
1:1 orthologGSK3BI6ZJZ7Sus scrofaPredictionMore>>
1:1 orthologGSK3B100348842A0A5F9CM08Oryctolagus cuniculusPredictionMore>>
1:1 orthologGsk3b84027A0A0G2KB98Rattus norvegicusPredictionMore>>
1:1 orthologgsk3ba30654Q9YH60Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005524 ATP binding
GO:0004674 protein serine/threonine kinase activity

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0067 ATP-binding
KW-0418 Kinase
KW-0547 Nucleotide-binding
KW-1185 Reference proteome
KW-0723 Serine/threonine-protein kinase
KW-0808 Transferase

Interpro

InterPro ID InterPro Term
IPR033573 GSK3B
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR039192 STKc_GSK3

PROSITE

PROSITE ID PROSITE Term
PS00107 PROTEIN_KINASE_ATP
PS50011 PROTEIN_KINASE_DOM
PS00108 PROTEIN_KINASE_ST

Pfam

Pfam ID Pfam Term
PF00069 Pkinase