| Tag | Content |
|---|---|
| Uniprot ID | E2RRG5 |
| Entrez ID | 481513 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_005626556.2 |
| Ensembl protein ID | ENSCAFP00000001499 |
| Ensembl nucleotide ID | ENSCAFG00000001065 |
| Gene name | Homeobox protein |
| Gene symbol | PITX1 |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MDAFKGGMSL ERLPEGLRPP PPPHDMGPAF HLARAADPRE PLENSASESS DTELPEKERG 60 GEVKGPEDSG AGGAGCGGAE DPAKKKKQRR QRTHFTSQQL QELEATFQRN RYPDMSMREE 120 IAVWTNLTEP RVRVWFKNRR AKWRKRERNQ QLDLCKGGYV PQFSGLVQPY EDVYAAGYSY 180 NNWAAKSLAP APLSTKSFTF FNSMSPLSSQ SMFSAPSSIS SMTMPSSMGP GAVPGMPNSG 240 LNNINNLTGS SLNSAMSPGA CPYGTPASPY SVYRDTCNSS LASLRLKSKQ HSSFGYGGLQ 300 GPASGLNACQ YNS 313 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PITX1 | 508754 | F1MU46 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | PITX1 | 481513 | E2RRG5 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | PITX1 | 102181864 | A0A452DRM8 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | PITX1 | 5307 | P78337 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Pitx1 | 18740 | P70314 | CPO | E12.5, E13.5, E14.5, E15.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | PITX1 | 462072 | A0A2J8LRP3 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | PITX1 | 100689266 | F8SIP6 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Pitx1 | 113983 | Q99NA7 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | pitx1 | B2LT56 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005634 | nucleus |
| GO:0005667 | transcription factor complex |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0001085 | RNA polymerase II transcription factor binding |
| GO:0043565 | sequence-specific DNA binding |
| GO:0009653 | anatomical structure morphogenesis |
| GO:0014707 | branchiomeric skeletal muscle development |
| GO:0051216 | cartilage development |
| GO:0035116 | embryonic hindlimb morphogenesis |
| GO:0048625 | myoblast fate commitment |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0021983 | pituitary gland development |