| Tag | Content |
|---|---|
| Uniprot ID | Q99NA7 |
| Entrez ID | 113983 |
| Genbank protein ID | BAB41202.1; AAH61966.1; |
| Genbank nucleotide ID | XM_006253569.3; NM_053624.2; |
| Ensembl protein ID | ENSRNOP00000015307 |
| Ensembl nucleotide ID | ENSRNOG00000011423 |
| Gene name | Pituitary homeobox 1 |
| Gene symbol | Pitx1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb. |
| Sequence | MDAFKGGMSL ERLPEGLRPP PPPPHDMGPS FHLARTADPR EPLENSASES SDADLPDKER 60 GGEAKVPEDG GAGSAGCGSA EDPAKKKKQR RQRTHFTSQQ LQELEATFQR NRYPDMSMRE 120 EIAVWTNLTE PRVRVWFKNR RAKWRKRERN QQLDLCKGGY VPQFSGLVQP YEDVYAAAGY 180 SYNNWAAKSL APAPLSTKSF TFFNSMSPLS SQSMFSAPSS ISSMTMPSSM GPGSVPGMPN 240 SGLNNINNLT GSSLNSAMSP GACPYGTPAS PYSVYRDTCN SSLASLRLKS KQHSSFGYGG 300 LQGPASGLNA CQYNS 315 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PITX1 | 508754 | F1MU46 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | PITX1 | 481513 | E2RRG5 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | PITX1 | 102181864 | A0A452DRM8 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | PITX1 | 5307 | P78337 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Pitx1 | 18740 | P70314 | CPO | E12.5, E13.5, E14.5, E15.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | PITX1 | 462072 | A0A2J8LRP3 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | PITX1 | 100689266 | F8SIP6 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Pitx1 | 113983 | Q99NA7 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | pitx1 | B2LT56 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005634 | nucleus |
| GO:0005667 | transcription factor complex |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0001085 | RNA polymerase II transcription factor binding |
| GO:0043565 | sequence-specific DNA binding |
| GO:0009653 | anatomical structure morphogenesis |
| GO:0014707 | branchiomeric skeletal muscle development |
| GO:0051216 | cartilage development |
| GO:0035116 | embryonic hindlimb morphogenesis |
| GO:0035137 | hindlimb morphogenesis |
| GO:0048625 | myoblast fate commitment |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0021983 | pituitary gland development |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0006355 | regulation of transcription, DNA-templated |
| GO:0001501 | skeletal system development |