| Tag | Content |
|---|---|
| Uniprot ID | F1MU46 |
| Entrez ID | 508754 |
| Genbank protein ID | |
| Genbank nucleotide ID | NM_001205300.1 |
| Ensembl protein ID | ENSBTAP00000006039 |
| Ensembl nucleotide ID | ENSBTAG00000004602 |
| Gene name | Homeobox protein |
| Gene symbol | PITX1 |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MDAFKGGMSL ERLPEGLRPP PPQPHDMGPA FHLARTADPR EPLENSASES SDTELPEKER 60 GGEPKGPEDS GAGGAGCGGA EDPAKKKKQR RQRTHFTSQQ LQELEATFQR NRYPDMSMRE 120 EIAVWTNLTE PRVRVWFKNR RAKWRKRERN QQLDLCKGGY VPQFSGLVQP YDDVYAAGYS 180 YNNWAAKSLA PAPLSTKSFT FFNSMSPLSS QSMFSAPSSI SSMTMPSSMG PGAVPGMPNS 240 GLNNINNLTG SSLNSAMSPG ACPYGTPASP YSVYRDTCNS SLASLRLKSK QHSSFGYGGL 300 QGPASGLNAC QYNS 314 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PITX1 | 508754 | F1MU46 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | PITX1 | 481513 | E2RRG5 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | PITX1 | 102181864 | A0A452DRM8 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | PITX1 | 5307 | P78337 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Pitx1 | 18740 | P70314 | CPO | E12.5, E13.5, E14.5, E15.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | PITX1 | 462072 | A0A2J8LRP3 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | PITX1 | 100689266 | F8SIP6 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Pitx1 | 113983 | Q99NA7 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | pitx1 | B2LT56 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005634 | nucleus |
| GO:0005667 | transcription factor complex |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0001085 | RNA polymerase II transcription factor binding |
| GO:0043565 | sequence-specific DNA binding |
| GO:0009653 | anatomical structure morphogenesis |
| GO:0014707 | branchiomeric skeletal muscle development |
| GO:0051216 | cartilage development |
| GO:0035116 | embryonic hindlimb morphogenesis |
| GO:0048625 | myoblast fate commitment |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0021983 | pituitary gland development |