Gene: COMMD3

Basic information

Tag Content
Uniprot ID E2RTM4
Entrez ID 487097
Genbank protein ID
Genbank nucleotide ID XM_005617015.2; NM_001287063.1; XM_005617014.2;
Ensembl protein ID ENSCAFP00000006187
Ensembl nucleotide ID ENSCAFG00000004164
Gene name RING-type domain-containing protein
Gene symbol COMMD3
Organism Canis lupus familiaris
NCBI taxa ID 9615
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MHRTTRIKIT ELNPHLMCVL CGGYFIDATT IIECLHSFCK TCIVRYLETS KYCPICDVQV 60
HKTRPLLNIR SDKTLQDIVY KLVPGLFKNE MKRRRDFYAA HPSADAANGS NEDRGEVADE 120
DKRIITDDEI ISLSIEFFDQ NRLDRKVNKD KEKPKEEVND KRYLRCPAAM TVMHLRKFLR 180
SKMDIPNTFQ IDVMYEEEPL KDYYTLMDIA YIYTWRRNGP LPLKYRVRPT CKRMKMSHQR 240
DGLTNAGELE SDSGSDKANS PAGGAPSTSS CLPSPSTPVQ SPHPQFPHIS STMNGTSSSP 300
SGNHQSSFAN RPRKSSVNGS SATSSG 326

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologBMI1510666Q32KX7Bos taurusPredictionMore>>
1:1 orthologCOMMD3487097E2RTM4Canis lupus familiarisPredictionMore>>
1:1 orthologBMI1102191809A0A452EWQ5Capra hircusPredictionMore>>
1:1 orthologCOMMD3-BMI1100532731R4GMX3Homo sapiensPredictionMore>>
1:1 orthologBmi112151P25916CPOE14.5Mus musculusPublicationMore>>
1:1 orthologBMI1466023A0A2I3SRC0Pan troglodytesPredictionMore>>
1:1 orthologBMI1A0A287A130Sus scrofaPredictionMore>>
1:1 orthologBMI1100009347G1SNW4Oryctolagus cuniculusPredictionMore>>
1:1 orthologBmi1307151B4F7B6Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0035102 PRC1 complex
GO:1990841 promoter-specific chromatin binding
GO:0006342 chromatin silencing
GO:0036353 histone H2A-K119 monoubiquitination
GO:0000122 negative regulation of transcription by RNA polymerase II

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0479 Metal-binding
KW-1185 Reference proteome
KW-0862 Zinc
KW-0863 Zinc-finger

Interpro

InterPro ID InterPro Term
IPR032443 RAWUL
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS

PROSITE

PROSITE ID PROSITE Term
PS00518 ZF_RING_1
PS50089 ZF_RING_2

Pfam

Pfam ID Pfam Term
PF16207 RAWUL