Gene: BMI1

Basic information

Tag Content
Uniprot ID G1SNW4
Entrez ID 100009347
Genbank protein ID
Genbank nucleotide ID XM_008268280.2; XM_008268279.2; XM_008268278.2; XM_008268277.2;
Ensembl protein ID ENSOCUP00000004703
Ensembl nucleotide ID ENSOCUG00000005420
Gene name RING-type domain-containing protein
Gene symbol BMI1
Organism Oryctolagus cuniculus
NCBI taxa ID 9986
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MHRTTRIKIT ELNPHLMCVL CGGYFIDATT IIECLHSFCK TCIVRYLETS KYCPICDVQV 60
HKTRPLLNIR SDKTLQDIVY KLVPGLFKNE MKRRRDFYAA HPSADAANGS NEDRGEVADE 120
DKRIITDDEI ISLSIEFFDQ NRLDRKVSKD KEKSKEEVND KRYLRCPAAM TVMHLRKFLR 180
SKMDIPNTFQ IDVMYEEEPL KDYYTLMDIA YIYTWRRNGP LPLKYRVRPT CKRMKISHQR 240
DGLTNAGELE SDSGSDKANS PAGGIPSTSS CLPSPTTPVQ SPHPQFPHIS STMNGTSNSP 300
SGNHQSSFAN RPRKSSVNGS SATSSG 326

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologBMI1510666Q32KX7Bos taurusPredictionMore>>
1:1 orthologCOMMD3487097E2RTM4Canis lupus familiarisPredictionMore>>
1:1 orthologBMI1102191809A0A452EWQ5Capra hircusPredictionMore>>
1:1 orthologCOMMD3-BMI1100532731R4GMX3Homo sapiensPredictionMore>>
1:1 orthologBmi112151P25916CPOE14.5Mus musculusPublicationMore>>
1:1 orthologBMI1466023A0A2I3SRC0Pan troglodytesPredictionMore>>
1:1 orthologBMI1A0A287A130Sus scrofaPredictionMore>>
1:1 orthologBMI1100009347G1SNW4Oryctolagus cuniculusPredictionMore>>
1:1 orthologBmi1307151B4F7B6Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0000792 heterochromatin
GO:0016604 nuclear body
GO:0031519 PcG protein complex
GO:0000151 ubiquitin ligase complex
GO:1990841 promoter-specific chromatin binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0097027 ubiquitin-protein transferase activator activity
GO:0007420 brain development
GO:0006306 DNA methylation
GO:0048704 embryonic skeletal system morphogenesis
GO:0016573 histone acetylation
GO:0016574 histone ubiquitination
GO:0006959 humoral immune response
GO:0001701 in utero embryonic development
GO:2001234 negative regulation of apoptotic signaling pathway
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0030890 positive regulation of B cell proliferation
GO:0033092 positive regulation of immature T cell proliferation in thymus
GO:2000011 regulation of adaxial/abaxial pattern formation
GO:0021903 rostrocaudal neural tube patterning
GO:0048103 somatic stem cell division

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0479 Metal-binding
KW-1185 Reference proteome
KW-0862 Zinc
KW-0863 Zinc-finger

Interpro

InterPro ID InterPro Term
IPR032443 RAWUL
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS

PROSITE

PROSITE ID PROSITE Term
PS00518 ZF_RING_1
PS50089 ZF_RING_2

Pfam

Pfam ID Pfam Term
PF16207 RAWUL