| Tag | Content |
|---|---|
| Uniprot ID | Q32KX7 |
| Entrez ID | 510666 |
| Genbank protein ID | AAI09872.1 |
| Genbank nucleotide ID | NM_001038072.1 |
| Ensembl protein ID | ENSBTAP00000066261; ENSBTAP00000020705; ENSBTAP00000058683; |
| Ensembl nucleotide ID | ENSBTAG00000015584 |
| Gene name | Polycomb complex protein BMI-1 |
| Gene symbol | BMI1 |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2. |
| Sequence | MHRTTRIKIT ELNPHLMCVL CGGYFIDATT IIECLHSFCK TCIVRYLETS KYCPICDVQV 60 HKTRPLLNIR SDKTLQDIVY KLVPGLFKNE MKRRRDFYAA HPSADAANGS NEDRGEVADE 120 DKRIITDDEI ISLSIEFFDQ NRLDRKINKD KEKSKEEVND KRYLRCPAAM TVMHLRKFLR 180 SKMDIPNTFQ IDVMYEEEPL KDYYTLMDIA YIYTWRRNGP LPLKYRVRPT CKRMKISHQR 240 DGLTNTGELE SDSGSDKANS PAGGIPSTSS CLPSPSTPVQ SPHPQFPHIS STMNGTSSSP 300 SGNHQSSFAN RPRKSSVNGS SATSSG 326 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | BMI1 | 510666 | Q32KX7 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | COMMD3 | 487097 | E2RTM4 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | BMI1 | 102191809 | A0A452EWQ5 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | COMMD3-BMI1 | 100532731 | R4GMX3 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Bmi1 | 12151 | P25916 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | BMI1 | 466023 | A0A2I3SRC0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | BMI1 | A0A287A130 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | BMI1 | 100009347 | G1SNW4 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Bmi1 | 307151 | B4F7B6 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0000792 | heterochromatin |
| GO:0016604 | nuclear body |
| GO:0031519 | PcG protein complex |
| GO:0035102 | PRC1 complex |
| GO:0000151 | ubiquitin ligase complex |
| GO:1990841 | promoter-specific chromatin binding |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0097027 | ubiquitin-protein transferase activator activity |
| GO:0008270 | zinc ion binding |
| GO:0007420 | brain development |
| GO:0006342 | chromatin silencing |
| GO:0006306 | DNA methylation |
| GO:0048704 | embryonic skeletal system morphogenesis |
| GO:0016573 | histone acetylation |
| GO:0036353 | histone H2A-K119 monoubiquitination |
| GO:0006959 | humoral immune response |
| GO:0001701 | in utero embryonic development |
| GO:2001234 | negative regulation of apoptotic signaling pathway |
| GO:0045814 | negative regulation of gene expression, epigenetic |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0030890 | positive regulation of B cell proliferation |
| GO:0033092 | positive regulation of immature T cell proliferation in thymus |
| GO:0051443 | positive regulation of ubiquitin-protein transferase activity |
| GO:2000011 | regulation of adaxial/abaxial pattern formation |
| GO:0021903 | rostrocaudal neural tube patterning |
| GO:0048103 | somatic stem cell division |
| Pfam ID | Pfam Term |
|---|---|
| PF16207 | RAWUL |