| Tag | Content |
|---|---|
| Uniprot ID | E7F888 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | |
| Ensembl nucleotide ID | |
| Gene name | AT-rich interactive domain-containing protein 5B |
| Gene symbol | arid5b |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes (By similarity). |
| Sequence | MVSDLRSWKK GLQAVPLKPG VLKELGKNGQ REALHKYRES TLNSGLNFKD VLKEKAELGE 60 DADDKKVLVL SYPQYCRYRS IIARLRERPS SLLTDHVVLA LGGIASLTNS TQILYCRDTF 120 EHPTLVENES VCDEFAPNLK GRPRKKKLSI SQRRDSQSGG ARESNGVEGK TLVKMRADSK 180 SGVSKPRNPS TGSCKRVQSE NKPKGDGGDE CRTDEQAFLV ALYKYMKERK TPIERIPYLG 240 FKQINLWTMF QAAQKLGGYE VITARRQWKN VYDELGGNPG STSAATCTRR HYERLILPYE 300 RFTKGEEDKP LPPAKPRKQE GSVQESIIKA KMMPIKRPKD EQKTPRGDKD ASAKVLELGM 360 EDMEELQEKQ NSQQLQAPTQ TDRDPNSPLT EDDEGVLVIK DEDQPVLHNA YEHANGGLLP 420 SLPQDGAQLK SEDCDAFPVA AVPLHHGHPL PNSHTSDQWK HGILEYKVPP SALANVEQSR 480 PKEGQNQVVM VLPTLQQKPV TSPEIPPERV EPLKKEESCF NFNPLLYPRG NPGIMSPLAK 540 KKMLSQVSGT GLLNNYPYGP PPPLVSRRLS SSGTEVSSAG QSSSQVSSSV ETSIVIKRPS 600 VIQHAQSFKS RGSEDRRSST EGSQKDGCSE GEPVHHSQTL IREPYLKRVD PHSSMEKSAE 660 MPRPGQAPSF LSEFYSSPHL HNLCRQTEHH LSKEQISKYL SRDVYTRDSE TAQGFPPSQH 720 PDNVGLNFSA RLSQKEKGPP PERVTEEQPT DLSLPKSSPL KLPLSTSTLG GIPHAAIQQD 780 IKNSPHFQAG NSQSSSVDYH PRACRVPPMT VSASKKVTES HSKVLEKTPN SRGEESMGFK 840 IDEMSRPILS TKSSPQNICT ARPLKRNIED LENGPTEKKI RAVTPLHCST QRDLPGKPRT 900 PEADSESVKP AEPAVHINSY TSEGHKIPLH SHLFQGLYPG TFVSQVQDMC ESLGSHVTPS 960 YSHPLQYLKN QAVLSPLMPP FAIHSLMMQR QFLAANPAHM YRHQVGTSYG DILHPGLYPM 1020 SALHPQPAFS PPQLSSVHPS TKLS 1044 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ARID5B | 479217 | J9NV13 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | ARID5B | 102169735 | A0A452F8Y8 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | ARID5B | 84159 | Q14865 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Arid5b | 71371 | Q8BM75 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | ARID5B | 745725 | K7DSK8 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | ARID5B | 100352095 | G1U8W9 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | arid5b | E7F888 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0003713 | transcription coactivator activity |
| GO:0000976 | transcription regulatory region sequence-specific DNA binding |
| GO:0060612 | adipose tissue development |
| GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| GO:0006357 | regulation of transcription by RNA polymerase II |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51011 | ARID |
| Pfam ID | Pfam Term |
|---|---|
| PF01388 | ARID |