| Tag | Content |
|---|---|
| Uniprot ID | F1LMV3 |
| Entrez ID | 114502 |
| Genbank protein ID | |
| Genbank nucleotide ID | NM_053710.1 |
| Ensembl protein ID | ENSRNOP00000018652 |
| Ensembl nucleotide ID | ENSRNOG00000013670 |
| Gene name | Paired box 3 |
| Gene symbol | Pax3 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MTTLAGAVPR MMRPGPGQNY PRSGFPLEVS TPLGQGRVNQ LGGVFINGRP LPNHIRHKIV 60 EMAHHGIRPC VISRQLRVSH GCVSKILCRY QETGSIRPGA IGGSKPKQVT TPDVEKKIEE 120 YKRENPGMFS WEIRDKLLKD AVCDRNTVPS VSSISRILRS KFGKGEEEEA DLERKEAEES 180 EKKAKHSIDG ILSERASAPQ SDEGSDIDSE PDLPLKRKQR RSRTTFTAEQ LEELERAFER 240 THYPDIYTRE ELAQRAKLTE ARVQVWFSNR RARWRKQAGA NQLMAFNHLI PGGFPPTAMP 300 TLPTYQLSET SYQPTSIPQA VSDPSSTVHR PQPLPPSTVH QSTIPSNADS SSAYCLPSTR 360 HGFSSYTDSF VPPSGPSNPM NPAIGNGLSP QVMGLLTNHG GVPHQPQTDY ALSPLTGGLE 420 PTTTVSASCS QRLEHMKNVD SLPTSQPYCP PTYSTTGYSM DPVTGYQYGQ YGQSAFHYLK 480 PDIA 484 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PAX3 | 540951 | F1MTX0 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | PAX3 | A0A452FR15 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | PAX3 | 5077 | P23760 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Pax3 | 18505 | P24610 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | PAX3 | H2QJH9 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | PAX3 | I3LAG7 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Pax3 | 114502 | F1LMV3 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | pax3a | F1R7Y4 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005654 | nucleoplasm |
| GO:0005634 | nucleus |
| GO:0003682 | chromatin binding |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0071837 | HMG box domain binding |
| GO:0043565 | sequence-specific DNA binding |
| GO:0016477 | cell migration |
| GO:0008283 | cell population proliferation |
| GO:0048066 | developmental pigmentation |
| GO:0042063 | gliogenesis |
| GO:0007507 | heart development |
| GO:0060594 | mammary gland specification |
| GO:0007517 | muscle organ development |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0001755 | neural crest cell migration |
| GO:0001843 | neural tube closure |
| GO:0021915 | neural tube development |
| GO:0048663 | neuron fate commitment |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0014807 | regulation of somitogenesis |
| GO:0060538 | skeletal muscle organ development |
| GO:0021527 | spinal cord association neuron differentiation |