| Tag | Content |
|---|---|
| Uniprot ID | F1M077 |
| Entrez ID | 303181 |
| Genbank protein ID | |
| Genbank nucleotide ID | NM_001107005.2 |
| Ensembl protein ID | ENSRNOP00000063833 |
| Ensembl nucleotide ID | ENSRNOG00000003039 |
| Gene name | Protein Wnt |
| Gene symbol | Wnt3a |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Ligand for members of the frizzled family of seven transmembrane receptors. |
| Sequence | MYNLCVVVVV VAEVLTQQLN DRALTSRVLL WSLAVGPQYS SLSTQPILCA SIPGLVPKQL 60 RFCRNYVEIM PSVAEGVKAG IQECQHQFRG RRWNCTTVSN SLAIFGPVLD KATRESAFVH 120 AIASAGVAFA VTRSCAEGSA AICGCSSRLQ GSPGEGWKWG GCSEDIEFGG MVSREFADAR 180 ENRPDARSAM NRHNNEAGRQ AIASHMHLKC KCHGLSGSCE VKTCWWSQPD FRTIGDFLKD 240 KYDSASEMVV EKHRESRGWV ETLRPRYTYF KVPTERDLVY YEASPNFCEP NPETGSFGTR 300 DRTCNVSSHG IDGCDLLCCG RGHNARTERR REKCHCVFHW CCYVSCQECT RVYDVHTCK 359 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | WNT3A | A0A452ETX2 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | WNT3A | 89780 | P56704 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Wnt3a | 22416 | P27467 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | WNT3A | 100615247 | H2R817 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | 100514950 | A0A480RFN3 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | WNT3A | 100354583 | G1SKY6 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Wnt3a | 303181 | F1M077 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0009986 | cell surface |
| GO:0005615 | extracellular space |
| GO:0098978 | glutamatergic synapse |
| GO:0045202 | synapse |
| GO:1990851 | Wnt-Frizzled-LRP5/6 complex |
| GO:0039706 | co-receptor binding |
| GO:0005109 | frizzled binding |
| GO:0019904 | protein domain specific binding |
| GO:0048018 | receptor ligand activity |
| GO:0005102 | signaling receptor binding |
| GO:0003713 | transcription coactivator activity |
| GO:0009952 | anterior/posterior pattern specification |
| GO:0090245 | axis elongation involved in somitogenesis |
| GO:0007411 | axon guidance |
| GO:0007409 | axonogenesis |
| GO:0090676 | calcium ion transmembrane transport via low voltage-gated calcium channel |
| GO:0060070 | canonical Wnt signaling pathway |
| GO:0061317 | canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment |
| GO:0060923 | cardiac muscle cell fate commitment |
| GO:0045165 | cell fate commitment |
| GO:0008283 | cell population proliferation |
| GO:0021846 | cell proliferation in forebrain |
| GO:0033278 | cell proliferation in midbrain |
| GO:0034613 | cellular protein localization |
| GO:0010387 | COP9 signalosome assembly |
| GO:0007368 | determination of left/right symmetry |
| GO:0021904 | dorsal/ventral neural tube patterning |
| GO:0030198 | extracellular matrix organization |
| GO:0001947 | heart looping |
| GO:0030097 | hemopoiesis |
| GO:0021766 | hippocampus development |
| GO:0001701 | in utero embryonic development |
| GO:0042472 | inner ear morphogenesis |
| GO:0030879 | mammary gland development |
| GO:0007498 | mesoderm development |
| GO:0030901 | midbrain development |
| GO:0050804 | modulation of chemical synaptic transmission |
| GO:0048843 | negative regulation of axon extension involved in axon guidance |
| GO:1904339 | negative regulation of dopaminergic neuron differentiation |
| GO:0045599 | negative regulation of fat cell differentiation |
| GO:0003136 | negative regulation of heart induction by canonical Wnt signaling pathway |
| GO:0050768 | negative regulation of neurogenesis |
| GO:1901215 | negative regulation of neuron death |
| GO:0010977 | negative regulation of neuron projection development |
| GO:0022008 | neurogenesis |
| GO:0030182 | neuron differentiation |
| GO:0001649 | osteoblast differentiation |
| GO:0048343 | paraxial mesodermal cell fate commitment |
| GO:0030168 | platelet activation |
| GO:0070527 | platelet aggregation |
| GO:0030890 | positive regulation of B cell proliferation |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| GO:2000081 | positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation |
| GO:2000727 | positive regulation of cardiac muscle cell differentiation |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:2000049 | positive regulation of cell-cell adhesion mediated by cadherin |
| GO:0048697 | positive regulation of collateral sprouting in absence of injury |
| GO:1904798 | positive regulation of core promoter binding |
| GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| GO:0001819 | positive regulation of cytokine production |
| GO:0061184 | positive regulation of dermatome development |
| GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| GO:0010628 | positive regulation of gene expression |
| GO:2000347 | positive regulation of hepatocyte proliferation |
| GO:0048337 | positive regulation of mesodermal cell fate specification |
| GO:2000179 | positive regulation of neural precursor cell proliferation |
| GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| GO:0032092 | positive regulation of protein binding |
| GO:0045860 | positive regulation of protein kinase activity |
| GO:1903078 | positive regulation of protein localization to plasma membrane |
| GO:0001934 | positive regulation of protein phosphorylation |
| GO:0061098 | positive regulation of protein tyrosine kinase activity |
| GO:0002092 | positive regulation of receptor internalization |
| GO:0048643 | positive regulation of skeletal muscle tissue development |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0036342 | post-anal tail morphogenesis |
| GO:0099527 | postsynapse to nucleus signaling pathway |
| GO:0050770 | regulation of axonogenesis |
| GO:0045595 | regulation of cell differentiation |
| GO:0070507 | regulation of microtubule cytoskeleton organization |
| GO:1905606 | regulation of presynapse assembly |
| GO:2001141 | regulation of RNA biosynthetic process |
| GO:0050807 | regulation of synapse organization |
| GO:0062009 | secondary palate development |
| GO:0035914 | skeletal muscle cell differentiation |
| GO:0048103 | somatic stem cell division |
| GO:0001756 | somitogenesis |
| GO:0021527 | spinal cord association neuron differentiation |
| GO:0016055 | Wnt signaling pathway |
| GO:0021874 | Wnt signaling pathway involved in forebrain neuroblast division |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00246 | WNT1 |
| Pfam ID | Pfam Term |
|---|---|
| PF00110 | wnt |