| Tag | Content |
|---|---|
| Uniprot ID | H2R817; A0A2J8IT71; |
| Entrez ID | 100615247 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_003949709.2 |
| Ensembl protein ID | ENSPTRP00000051074 |
| Ensembl nucleotide ID | ENSPTRG00000002064 |
| Gene name | Protein Wnt |
| Gene symbol | WNT3A |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Ligand for members of the frizzled family of seven transmembrane receptors. |
| Sequence | MAPLGYFLLL CSLKQALGSY PIWWSLAVGP QYSSLGSQPI LCASIPGLVP KQLRFCRNYV 60 EIMPSVAEGI KIGIQECQHQ FRGRRWNCTT VHDSLAIFGP VLDKATRESA FVHAIASAGV 120 AFAVTRSCAE GTAAICGCSS RHQGSPGKGW KWGGCSEDIE FGGMVSREFA DARENRPDAR 180 SAMNRHNNEA GRQAIASHMH LKCKCHGLSG SCEVKTCWWS QPDFRAIGDF LKDKYDSASE 240 MVVEKHRESR GWVETLRPRY TYFKVPTERD LVYYEASPNF CEPNPETGSF GTRDRTCNVS 300 SHGIDGCDLL CCGRGHNARA ERRREKCRCV FHWCCYVSCQ ECTRVYDVHT CK 352 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | WNT3A | A0A452ETX2 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | WNT3A | 89780 | P56704 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Wnt3a | 22416 | P27467 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | WNT3A | 100615247 | H2R817 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | 100514950 | A0A480RFN3 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | WNT3A | 100354583 | G1SKY6 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Wnt3a | 303181 | F1M077 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0009986 | cell surface |
| GO:0005615 | extracellular space |
| GO:0098978 | glutamatergic synapse |
| GO:1990851 | Wnt-Frizzled-LRP5/6 complex |
| GO:0039706 | co-receptor binding |
| GO:0005109 | frizzled binding |
| GO:0019904 | protein domain specific binding |
| GO:0048018 | receptor ligand activity |
| GO:0003713 | transcription coactivator activity |
| GO:0090245 | axis elongation involved in somitogenesis |
| GO:0007411 | axon guidance |
| GO:0090676 | calcium ion transmembrane transport via low voltage-gated calcium channel |
| GO:0061317 | canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment |
| GO:0045165 | cell fate commitment |
| GO:0021846 | cell proliferation in forebrain |
| GO:0033278 | cell proliferation in midbrain |
| GO:0034613 | cellular protein localization |
| GO:0010387 | COP9 signalosome assembly |
| GO:0021904 | dorsal/ventral neural tube patterning |
| GO:0030198 | extracellular matrix organization |
| GO:0001947 | heart looping |
| GO:0030097 | hemopoiesis |
| GO:0021766 | hippocampus development |
| GO:0001701 | in utero embryonic development |
| GO:0042472 | inner ear morphogenesis |
| GO:0030879 | mammary gland development |
| GO:0050804 | modulation of chemical synaptic transmission |
| GO:0048843 | negative regulation of axon extension involved in axon guidance |
| GO:1904339 | negative regulation of dopaminergic neuron differentiation |
| GO:0045599 | negative regulation of fat cell differentiation |
| GO:0003136 | negative regulation of heart induction by canonical Wnt signaling pathway |
| GO:1901215 | negative regulation of neuron death |
| GO:0030182 | neuron differentiation |
| GO:0001649 | osteoblast differentiation |
| GO:0048343 | paraxial mesodermal cell fate commitment |
| GO:0070527 | platelet aggregation |
| GO:0030890 | positive regulation of B cell proliferation |
| GO:2000081 | positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation |
| GO:2000727 | positive regulation of cardiac muscle cell differentiation |
| GO:2000049 | positive regulation of cell-cell adhesion mediated by cadherin |
| GO:0048697 | positive regulation of collateral sprouting in absence of injury |
| GO:1904798 | positive regulation of core promoter binding |
| GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| GO:0001819 | positive regulation of cytokine production |
| GO:0061184 | positive regulation of dermatome development |
| GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| GO:2000347 | positive regulation of hepatocyte proliferation |
| GO:0048337 | positive regulation of mesodermal cell fate specification |
| GO:2000179 | positive regulation of neural precursor cell proliferation |
| GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| GO:0032092 | positive regulation of protein binding |
| GO:1903078 | positive regulation of protein localization to plasma membrane |
| GO:0061098 | positive regulation of protein tyrosine kinase activity |
| GO:0002092 | positive regulation of receptor internalization |
| GO:0048643 | positive regulation of skeletal muscle tissue development |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0036342 | post-anal tail morphogenesis |
| GO:0099527 | postsynapse to nucleus signaling pathway |
| GO:0070507 | regulation of microtubule cytoskeleton organization |
| GO:1905606 | regulation of presynapse assembly |
| GO:0062009 | secondary palate development |
| GO:0035914 | skeletal muscle cell differentiation |
| GO:0048103 | somatic stem cell division |
| GO:0021527 | spinal cord association neuron differentiation |
| GO:0016055 | Wnt signaling pathway |
| GO:0021874 | Wnt signaling pathway involved in forebrain neuroblast division |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00246 | WNT1 |
| Pfam ID | Pfam Term |
|---|---|
| PF00110 | wnt |