| Tag | Content |
|---|---|
| Uniprot ID | F1MZ14 |
| Entrez ID | 286815 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_002690949.5; XM_015465145.1; |
| Ensembl protein ID | ENSBTAP00000009020 |
| Ensembl nucleotide ID | ENSBTAG00000040151 |
| Gene name | GTP cyclohydrolase 1 |
| Gene symbol | GCH1 |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MEKGPGRVTL TSRGARCSNG FLEGEPPRPG PSPPAEKPPR PESKSAQPAD GWNGERPRSE 60 EDNELNLPNL AAAYSSILRS LGEDPERQGL IKTPWRAATA MQFFTKGYQE TISDVLNDAI 120 FDEDHDEMVI VKDIDMFSMC EHHLVPFVGK VHIGYLPNKQ VLGLSKLARI VEIYSRRLQV 180 QERLTKQIAV AIIEALRPAG VGVVVEATHM CMVMRGVQKM NSRTVTSTML GVFREDPKTR 240 EEFLSLIKS 249 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | GCH1 | 286815 | F1MZ14 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | GCH1 | 609393 | E2RI70 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | GCH1 | A0A452F7E4 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | GCH1 | 2643 | P30793 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Gch1 | 14528 | Q05915 | E14.5 | Mus musculus | Prediction | More>> | |
| 1:1 ortholog | GCH1 | A0A2I3RQP8 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | GCH1 | A0A287BGL7 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | GCH1 | 100286831 | G1SIY3 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Gch1 | 29244 | P22288 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | gch1 | 100192219 | E7FGQ8 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0031410 | cytoplasmic vesicle |
| GO:0005829 | cytosol |
| GO:0031965 | nuclear membrane |
| GO:0005654 | nucleoplasm |
| GO:0032991 | protein-containing complex |
| GO:0005525 | GTP binding |
| GO:0003934 | GTP cyclohydrolase I activity |
| GO:0003924 | GTPase activity |
| GO:0051019 | mitogen-activated protein kinase binding |
| GO:0042803 | protein homodimerization activity |
| GO:0008270 | zinc ion binding |
| GO:0042416 | dopamine biosynthetic process |
| GO:0050884 | neuromuscular process controlling posture |
| GO:0010460 | positive regulation of heart rate |
| GO:0051000 | positive regulation of nitric-oxide synthase activity |
| GO:0014916 | regulation of lung blood pressure |
| GO:2000121 | regulation of removal of superoxide radicals |
| GO:0034341 | response to interferon-gamma |
| GO:0032496 | response to lipopolysaccharide |
| GO:0034612 | response to tumor necrosis factor |
| GO:0006729 | tetrahydrobiopterin biosynthetic process |
| GO:0046654 | tetrahydrofolate biosynthetic process |
| Keyword ID | Keyword Term |
|---|---|
| KW-1185 | Reference proteome |
| Pfam ID | Pfam Term |
|---|---|
| PF01227 | GTP_cyclohydroI |