| Tag | Content |
|---|---|
| Uniprot ID | Q05915 |
| Entrez ID | 14528 |
| Genbank protein ID | AAH05643.1; AAH69921.1; AAC60677.2; AAA37757.1; |
| Genbank nucleotide ID | NM_008102.3 |
| Ensembl protein ID | ENSMUSP00000087405 |
| Ensembl nucleotide ID | ENSMUSG00000037580 |
| Gene name | GTP cyclohydrolase 1 |
| Gene symbol | Gch1 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | |
| Developmental stage | E14.5 |
| Data sources | Homology search |
| Reference | |
| Functional description | May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis. May modify pain sensitivity and persistence. |
| Sequence | MEKPRGVRCT NGFSERELPR PGASPPAEKS RPPEAKGAQP ADAWKAGRHR SEEENQVNLP 60 KLAAAYSSIL LSLGEDPQRQ GLLKTPWRAA TAMQYFTKGY QETISDVLND AIFDEDHDEM 120 VIVKDIDMFS MCEHHLVPFV GRVHIGYLPN KQVLGLSKLA RIVEIYSRRL QVQERLTKQI 180 AVAITEALQP AGVGVVIEAT HMCMVMRGVQ KMNSKTVTST MLGVFREDPK TREEFLTLIR 240 S 241 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
