| Tag | Content |
|---|---|
| Uniprot ID | P22288 |
| Entrez ID | 29244 |
| Genbank protein ID | AAA41299.1 |
| Genbank nucleotide ID | NM_024356.1 |
| Ensembl protein ID | ENSRNOP00000014821 |
| Ensembl nucleotide ID | ENSRNOG00000011039 |
| Gene name | GTP cyclohydrolase 1 |
| Gene symbol | Gch1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis (By similarity). May modify pain sensitivity and persistence. |
| Sequence | MEKPRGVRCT NGFPERELPR PGASRPAEKS RPPEAKGAQP ADAWKAGRPR SEEDNELNLP 60 NLAAAYSSIL RSLGEDPQRQ GLLKTPWRAA TAMQFFTKGY QETISDVLND AIFDEDHDEM 120 VIVKDIDMFS MCEHHLVPFV GRVHIGYLPN KQVLGLSKLA RIVEIYSRRL QVQERLTKQI 180 AVAITEALQP AGVGVVIEAT HMCMVMRGVQ KMNSKTVTST MLGVFREDPK TREEFLTLIR 240 S 241 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | GCH1 | 286815 | F1MZ14 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | GCH1 | 609393 | E2RI70 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | GCH1 | A0A452F7E4 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | GCH1 | 2643 | P30793 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Gch1 | 14528 | Q05915 | E14.5 | Mus musculus | Prediction | More>> | |
| 1:1 ortholog | GCH1 | A0A2I3RQP8 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | GCH1 | A0A287BGL7 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | GCH1 | 100286831 | G1SIY3 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Gch1 | 29244 | P22288 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | gch1 | 100192219 | E7FGQ8 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0031410 | cytoplasmic vesicle |
| GO:0005829 | cytosol |
| GO:0031965 | nuclear membrane |
| GO:0005654 | nucleoplasm |
| GO:0005634 | nucleus |
| GO:0032991 | protein-containing complex |
| GO:0005509 | calcium ion binding |
| GO:0050662 | coenzyme binding |
| GO:0005525 | GTP binding |
| GO:0003934 | GTP cyclohydrolase I activity |
| GO:0030742 | GTP-dependent protein binding |
| GO:0003924 | GTPase activity |
| GO:0042802 | identical protein binding |
| GO:0051019 | mitogen-activated protein kinase binding |
| GO:0042803 | protein homodimerization activity |
| GO:0044877 | protein-containing complex binding |
| GO:0031369 | translation initiation factor binding |
| GO:0008270 | zinc ion binding |
| GO:0035998 | 7,8-dihydroneopterin 3'-triphosphate biosynthetic process |
| GO:0051066 | dihydrobiopterin metabolic process |
| GO:0042416 | dopamine biosynthetic process |
| GO:0045776 | negative regulation of blood pressure |
| GO:0050884 | neuromuscular process controlling posture |
| GO:0010460 | positive regulation of heart rate |
| GO:0051000 | positive regulation of nitric-oxide synthase activity |
| GO:0065003 | protein-containing complex assembly |
| GO:0042559 | pteridine-containing compound biosynthetic process |
| GO:0008217 | regulation of blood pressure |
| GO:0014916 | regulation of lung blood pressure |
| GO:2000121 | regulation of removal of superoxide radicals |
| GO:0034341 | response to interferon-gamma |
| GO:0032496 | response to lipopolysaccharide |
| GO:0048265 | response to pain |
| GO:0034612 | response to tumor necrosis factor |
| GO:0006729 | tetrahydrobiopterin biosynthetic process |
| GO:0046654 | tetrahydrofolate biosynthetic process |
| GO:0042311 | vasodilation |
| Keyword ID | Keyword Term |
|---|---|
| KW-0002 | 3D-structure |
| KW-0021 | Allosteric enzyme |
| KW-0963 | Cytoplasm |
| KW-0903 | Direct protein sequencing |
| KW-0342 | GTP-binding |
| KW-0378 | Hydrolase |
| KW-0479 | Metal-binding |
| KW-0547 | Nucleotide-binding |
| KW-0539 | Nucleus |
| KW-0597 | Phosphoprotein |
| KW-1185 | Reference proteome |
| KW-0783 | Tetrahydrobiopterin biosynthesis |
| KW-0862 | Zinc |
| Pfam ID | Pfam Term |
|---|---|
| PF01227 | GTP_cyclohydroI |