Gene: GCH1

Basic information

Tag Content
Uniprot ID G1SIY3
Entrez ID 100286831
Genbank protein ID
Genbank nucleotide ID XM_002718258.3
Ensembl protein ID ENSOCUP00000002657
Ensembl nucleotide ID ENSOCUG00000003060
Gene name GTP_cyclohydroI domain-containing protein
Gene symbol GCH1
Organism Oryctolagus cuniculus
NCBI taxa ID 9986
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MEKGPVRALA ETPRGARCSN GFPEREPPRP GPSRPAEKPP RPEAGGAPTA DGWKGERPRS 60
EEDNELNLPN LAAAYASILR SLGEDPQRQG LLKTPWRAAT AMQFFTKGYQ ETISDVLNDA 120
IFDEDHDEMV IVKDIDMFSM CEHHLVPFVG KVHIGYLPNK QVLGLSKLAR IVEIYSRRLQ 180
VQERLTKQIA VAITEALHPA GVGVVVEATH MCMVMRGVQK MNSKTVTSTM LGVFREDPKT 240
REEFLTLIRS

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologGCH1286815F1MZ14Bos taurusPredictionMore>>
1:1 orthologGCH1609393E2RI70Canis lupus familiarisPredictionMore>>
1:1 orthologGCH1A0A452F7E4Capra hircusPredictionMore>>
1:1 orthologGCH12643P30793Homo sapiensPublicationMore>>
1:1 orthologGch114528Q05915E14.5Mus musculusPredictionMore>>
1:1 orthologGCH1A0A2I3RQP8Pan troglodytesPredictionMore>>
1:1 orthologGCH1A0A287BGL7Sus scrofaPredictionMore>>
1:1 orthologGCH1100286831G1SIY3Oryctolagus cuniculusPredictionMore>>
1:1 orthologGch129244P22288Rattus norvegicusPredictionMore>>
1:1 orthologgch1100192219E7FGQ8Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0003934 GTP cyclohydrolase I activity
GO:0046654 tetrahydrofolate biosynthetic process

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR043133 GTP-CH-I_C/QueF
IPR043134 GTP-CH-I_N
IPR001474 GTP_CycHdrlase_I
IPR018234 GTP_CycHdrlase_I_CS
IPR020602 GTP_CycHdrlase_I_dom

PROSITE

PROSITE ID PROSITE Term
PS00859 GTP_CYCLOHYDROL_1_1
PS00860 GTP_CYCLOHYDROL_1_2

Pfam

Pfam ID Pfam Term
PF01227 GTP_cyclohydroI