| Tag | Content |
|---|---|
| Uniprot ID | F1N6G8 |
| Entrez ID | 326284 |
| Genbank protein ID | |
| Genbank nucleotide ID | NM_001206678.1 |
| Ensembl protein ID | ENSBTAP00000002001 |
| Ensembl nucleotide ID | ENSBTAG00000001530 |
| Gene name | Fibroblast growth factor |
| Gene symbol | FGF8 |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MGSPRSALSC LLLHLLVLCL QAQEGPGGGP ALGRELASLF RAGRESQGVS QQVTVQSSPN 60 FTQHVREQSL VTDQLSRRLI RTYQLYSRTS GKHVQVLANK RINAMAEDGD PFAKLIVETD 120 TFGSRVRVRG AETGLYICMN KKGKLIAKSN GKGKDCVFTE IVLENNYTAL QNAKYEGWYM 180 AFTRKGRPRK GSKTRQHQRE VHFMKRLPRG HHTTEQSLRF EFLNYPPFTR SLRGSQRTWA 240 PEPR 244 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | FGF8 | 326284 | F1N6G8 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | FGF8 | A0A452EXW2 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | FGF8 | 2253 | P55075 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Fgf8 | 14179 | P37237 | CPO,CLP | E13.5, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | FGF8 | H2Q2G4 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | FGF8 | A0A287B086 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Fgf8 | 29349 | Q76LI5 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | fgf8a | A2CF52 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005576 | extracellular region |
| GO:0005104 | fibroblast growth factor receptor binding |
| GO:0008083 | growth factor activity |
| GO:0035909 | aorta morphogenesis |
| GO:0001974 | blood vessel remodeling |
| GO:0060348 | bone development |
| GO:0001569 | branching involved in blood vessel morphogenesis |
| GO:0060445 | branching involved in salivary gland morphogenesis |
| GO:0001658 | branching involved in ureteric bud morphogenesis |
| GO:0045165 | cell fate commitment |
| GO:0090134 | cell migration involved in mesendoderm migration |
| GO:0021846 | cell proliferation in forebrain |
| GO:0060128 | corticotropin hormone secreting cell differentiation |
| GO:0071542 | dopaminergic neuron differentiation |
| GO:0035116 | embryonic hindlimb morphogenesis |
| GO:0048702 | embryonic neurocranium morphogenesis |
| GO:0003198 | epithelial to mesenchymal transition involved in endocardial cushion formation |
| GO:0008543 | fibroblast growth factor receptor signaling pathway |
| GO:0021798 | forebrain dorsal/ventral pattern formation |
| GO:0048853 | forebrain morphogenesis |
| GO:0008406 | gonad development |
| GO:0001947 | heart looping |
| GO:0060425 | lung morphogenesis |
| GO:0030539 | male genitalia development |
| GO:0000165 | MAPK cascade |
| GO:0008078 | mesodermal cell migration |
| GO:0001656 | metanephros development |
| GO:0030917 | midbrain-hindbrain boundary development |
| GO:0055026 | negative regulation of cardiac muscle tissue development |
| GO:0043524 | negative regulation of neuron apoptotic process |
| GO:0001839 | neural plate morphogenesis |
| GO:0042476 | odontogenesis |
| GO:0001759 | organ induction |
| GO:0030916 | otic vesicle formation |
| GO:0003148 | outflow tract septum morphogenesis |
| GO:0021543 | pallium development |
| GO:0060037 | pharyngeal system development |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| GO:0045745 | positive regulation of G protein-coupled receptor signaling pathway |
| GO:0010628 | positive regulation of gene expression |
| GO:0045840 | positive regulation of mitotic nuclear division |
| GO:0046622 | positive regulation of organ growth |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| GO:0042487 | regulation of odontogenesis of dentin-containing tooth |
| GO:0023019 | signal transduction involved in regulation of gene expression |
| GO:0021544 | subpallium development |
| GO:0030878 | thyroid gland development |
| GO:0060129 | thyroid-stimulating hormone-secreting cell differentiation |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00247 | HBGF_FGF |
| Pfam ID | Pfam Term |
|---|---|
| PF00167 | FGF |