| Tag | Content |
|---|---|
| Uniprot ID | P55075; A1A514; Q14915; Q15766; |
| Entrez ID | 2253 |
| Genbank protein ID | AAB40955.1; AAC50783.1; AAC50782.1; EAW49746.1; AAB34255.1; AAM55238.1; AAI28236.1; AAB40953.1; AAC50785.1; AAB17894.1; AAB03787.1; BAA28605.1; AAB40954.1; BAA22527.1; AAB17893.1; AAC50784.1; |
| Genbank nucleotide ID | NM_033165.3; NM_033163.3; NM_006119.4; NM_033164.3; |
| Ensembl protein ID | ENSP00000321945; ENSP00000321797; ENSP00000344306; ENSP00000340039; |
| Ensembl nucleotide ID | ENSG00000107831 |
| Gene name | Fibroblast growth factor 8 |
| Gene symbol | FGF8 |
| Organism | Homo sapiens |
| NCBI taxa ID | 9606 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system (PubMed:16384934, PubMed:16597617, PubMed:8663044). Plays a role in neurite outgrowth in hippocampal cells (PubMed:21576111). |
| Sequence | MGSPRSALSC LLLHLLVLCL QAQEGPGRGP ALGRELASLF RAGREPQGVS QQHVREQSLV 60 TDQLSRRLIR TYQLYSRTSG KHVQVLANKR INAMAEDGDP FAKLIVETDT FGSRVRVRGA 120 ETGLYICMNK KGKLIAKSNG KGKDCVFTEI VLENNYTALQ NAKYEGWYMA FTRKGRPRKG 180 SKTRQHQREV HFMKRLPRGH HTTEQSLRFE FLNYPPFTRS LRGSQRTWAP EPR 233 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.