Gene: Fgf8

Basic information

Tag Content
Uniprot ID Q76LI5; D4A7C7;
Entrez ID 29349
Genbank protein ID BAB84359.1; EDL94316.1;
Genbank nucleotide ID NM_133286.1
Ensembl protein ID ENSRNOP00000023558
Ensembl nucleotide ID ENSRNOG00000017524
Gene name Fibroblast growth factor
Gene symbol Fgf8
Organism Rattus norvegicus
NCBI taxa ID 10116
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MGSPRSALSC LLLHLLVLCL QAQHVREQSL VTDQLSRRLI RTYQLYSRTS GKHVQVLANK 60
RINAMAEDGD PFAKLIVETD TFGSRVRVRG AETGLYICMN KKGKLIAKSN GKGKDCVFTE 120
IVLENNYTAL QNAKYEGWYM AFTRKGRPRK GSKTRQHQRE VHFMKRLPRG HHTTEQSLRF 180
EFLNYPPFTR SLRGSQRTWA PEPR 204

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologFGF8326284F1N6G8Bos taurusPredictionMore>>
1:1 orthologFGF8A0A452EXW2Capra hircusPredictionMore>>
1:1 orthologFGF82253P55075Homo sapiensPredictionMore>>
1:1 orthologFgf814179P37237CPO,CLPE13.5, E16.5Mus musculusPublicationMore>>
1:1 orthologFGF8H2Q2G4Pan troglodytesPredictionMore>>
1:1 orthologFGF8A0A287B086Sus scrofaPredictionMore>>
1:1 orthologFgf829349Q76LI5Rattus norvegicusPredictionMore>>
1:1 orthologfgf8aA2CF52Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0009897 external side of plasma membrane
GO:0005615 extracellular space
GO:0042056 chemoattractant activity
GO:0008083 growth factor activity
GO:0005105 type 1 fibroblast growth factor receptor binding
GO:0005111 type 2 fibroblast growth factor receptor binding
GO:0035909 aorta morphogenesis
GO:0001974 blood vessel remodeling
GO:0060348 bone development
GO:0001569 branching involved in blood vessel morphogenesis
GO:0060445 branching involved in salivary gland morphogenesis
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0045165 cell fate commitment
GO:0090134 cell migration involved in mesendoderm migration
GO:0021846 cell proliferation in forebrain
GO:0021954 central nervous system neuron development
GO:0060128 corticotropin hormone secreting cell differentiation
GO:0007368 determination of left/right symmetry
GO:0071542 dopaminergic neuron differentiation
GO:0033563 dorsal/ventral axon guidance
GO:0009792 embryo development ending in birth or egg hatching
GO:0035050 embryonic heart tube development
GO:0035116 embryonic hindlimb morphogenesis
GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0021798 forebrain dorsal/ventral pattern formation
GO:0048853 forebrain morphogenesis
GO:0021884 forebrain neuron development
GO:0048699 generation of neurons
GO:0008406 gonad development
GO:0007507 heart development
GO:0001947 heart looping
GO:0003007 heart morphogenesis
GO:0042472 inner ear morphogenesis
GO:0001822 kidney development
GO:0035108 limb morphogenesis
GO:0030324 lung development
GO:0060425 lung morphogenesis
GO:0030539 male genitalia development
GO:0000165 MAPK cascade
GO:0008078 mesodermal cell migration
GO:0001823 mesonephros development
GO:0001656 metanephros development
GO:0030917 midbrain-hindbrain boundary development
GO:0008045 motor neuron axon guidance
GO:0043066 negative regulation of apoptotic process
GO:0055026 negative regulation of cardiac muscle tissue development
GO:0043524 negative regulation of neuron apoptotic process
GO:0001839 neural plate morphogenesis
GO:0060563 neuroepithelial cell differentiation
GO:0042476 odontogenesis
GO:0001759 organ induction
GO:0030916 otic vesicle formation
GO:0003151 outflow tract morphogenesis
GO:0003148 outflow tract septum morphogenesis
GO:0021543 pallium development
GO:0060037 pharyngeal system development
GO:0008284 positive regulation of cell population proliferation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0045745 positive regulation of G protein-coupled receptor signaling pathway
GO:0010628 positive regulation of gene expression
GO:0045840 positive regulation of mitotic nuclear division
GO:0046622 positive regulation of organ growth
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0042487 regulation of odontogenesis of dentin-containing tooth
GO:0042493 response to drug
GO:0014070 response to organic cyclic compound
GO:0006979 response to oxidative stress
GO:0023019 signal transduction involved in regulation of gene expression
GO:0021544 subpallium development
GO:0021537 telencephalon development
GO:0030878 thyroid gland development
GO:0060129 thyroid-stimulating hormone-secreting cell differentiation

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0339 Growth factor
KW-1185 Reference proteome
KW-0732 Signal

Interpro

InterPro ID InterPro Term
IPR028249 FGF8
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF

PROSITE

PROSITE ID PROSITE Term
PS00247 HBGF_FGF

Pfam

Pfam ID Pfam Term
PF00167 FGF