| Tag | Content |
|---|---|
| Uniprot ID | Q76LI5; D4A7C7; |
| Entrez ID | 29349 |
| Genbank protein ID | BAB84359.1; EDL94316.1; |
| Genbank nucleotide ID | NM_133286.1 |
| Ensembl protein ID | ENSRNOP00000023558 |
| Ensembl nucleotide ID | ENSRNOG00000017524 |
| Gene name | Fibroblast growth factor |
| Gene symbol | Fgf8 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MGSPRSALSC LLLHLLVLCL QAQHVREQSL VTDQLSRRLI RTYQLYSRTS GKHVQVLANK 60 RINAMAEDGD PFAKLIVETD TFGSRVRVRG AETGLYICMN KKGKLIAKSN GKGKDCVFTE 120 IVLENNYTAL QNAKYEGWYM AFTRKGRPRK GSKTRQHQRE VHFMKRLPRG HHTTEQSLRF 180 EFLNYPPFTR SLRGSQRTWA PEPR 204 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
Protein disorder visualization from D2P2 is currently unavailable.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | FGF8 | 326284 | F1N6G8 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | FGF8 | A0A452EXW2 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | FGF8 | 2253 | P55075 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Fgf8 | 14179 | P37237 | CPO,CLP | E13.5, E16.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | FGF8 | H2Q2G4 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | FGF8 | A0A287B086 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Fgf8 | 29349 | Q76LI5 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | fgf8a | A2CF52 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0009897 | external side of plasma membrane |
| GO:0005615 | extracellular space |
| GO:0042056 | chemoattractant activity |
| GO:0008083 | growth factor activity |
| GO:0005105 | type 1 fibroblast growth factor receptor binding |
| GO:0005111 | type 2 fibroblast growth factor receptor binding |
| GO:0035909 | aorta morphogenesis |
| GO:0001974 | blood vessel remodeling |
| GO:0060348 | bone development |
| GO:0001569 | branching involved in blood vessel morphogenesis |
| GO:0060445 | branching involved in salivary gland morphogenesis |
| GO:0001658 | branching involved in ureteric bud morphogenesis |
| GO:0045165 | cell fate commitment |
| GO:0090134 | cell migration involved in mesendoderm migration |
| GO:0021846 | cell proliferation in forebrain |
| GO:0021954 | central nervous system neuron development |
| GO:0060128 | corticotropin hormone secreting cell differentiation |
| GO:0007368 | determination of left/right symmetry |
| GO:0071542 | dopaminergic neuron differentiation |
| GO:0033563 | dorsal/ventral axon guidance |
| GO:0009792 | embryo development ending in birth or egg hatching |
| GO:0035050 | embryonic heart tube development |
| GO:0035116 | embryonic hindlimb morphogenesis |
| GO:0003198 | epithelial to mesenchymal transition involved in endocardial cushion formation |
| GO:0008543 | fibroblast growth factor receptor signaling pathway |
| GO:0021798 | forebrain dorsal/ventral pattern formation |
| GO:0048853 | forebrain morphogenesis |
| GO:0021884 | forebrain neuron development |
| GO:0048699 | generation of neurons |
| GO:0008406 | gonad development |
| GO:0007507 | heart development |
| GO:0001947 | heart looping |
| GO:0003007 | heart morphogenesis |
| GO:0042472 | inner ear morphogenesis |
| GO:0001822 | kidney development |
| GO:0035108 | limb morphogenesis |
| GO:0030324 | lung development |
| GO:0060425 | lung morphogenesis |
| GO:0030539 | male genitalia development |
| GO:0000165 | MAPK cascade |
| GO:0008078 | mesodermal cell migration |
| GO:0001823 | mesonephros development |
| GO:0001656 | metanephros development |
| GO:0030917 | midbrain-hindbrain boundary development |
| GO:0008045 | motor neuron axon guidance |
| GO:0043066 | negative regulation of apoptotic process |
| GO:0055026 | negative regulation of cardiac muscle tissue development |
| GO:0043524 | negative regulation of neuron apoptotic process |
| GO:0001839 | neural plate morphogenesis |
| GO:0060563 | neuroepithelial cell differentiation |
| GO:0042476 | odontogenesis |
| GO:0001759 | organ induction |
| GO:0030916 | otic vesicle formation |
| GO:0003151 | outflow tract morphogenesis |
| GO:0003148 | outflow tract septum morphogenesis |
| GO:0021543 | pallium development |
| GO:0060037 | pharyngeal system development |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| GO:0045745 | positive regulation of G protein-coupled receptor signaling pathway |
| GO:0010628 | positive regulation of gene expression |
| GO:0045840 | positive regulation of mitotic nuclear division |
| GO:0046622 | positive regulation of organ growth |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| GO:0042487 | regulation of odontogenesis of dentin-containing tooth |
| GO:0042493 | response to drug |
| GO:0014070 | response to organic cyclic compound |
| GO:0006979 | response to oxidative stress |
| GO:0023019 | signal transduction involved in regulation of gene expression |
| GO:0021544 | subpallium development |
| GO:0021537 | telencephalon development |
| GO:0030878 | thyroid gland development |
| GO:0060129 | thyroid-stimulating hormone-secreting cell differentiation |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00247 | HBGF_FGF |
| Pfam ID | Pfam Term |
|---|---|
| PF00167 | FGF |