Gene: SFN

Basic information

Tag Content
Uniprot ID F1PQ93
Entrez ID 487351
Genbank protein ID
Genbank nucleotide ID XM_005617741.1
Ensembl protein ID ENSCAFP00000018103
Ensembl nucleotide ID ENSCAFG00000012290
Gene name Stratifin
Gene symbol SFN
Organism Canis lupus familiaris
NCBI taxa ID 9615
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MERASLIQKA KLAEQAERYE DMAAFMKSAV EKGEELSCEE RNLLSVAYKN VVGGQRAAWR 60
VLSSIEQKGN EESSEEKGPE VREYREKVET ELRGVCDTVL GLLDSHLIKE AGDAESRVFY 120
LKMKGDYYRY LAEVATGDDK KRIIDSARSA YQEAMDISKK EMPPTNPIRL GLALNFSVFH 180
YEIANSPEEA ISLAKTTFDE AMADLHTLSE DSYKDSTLIM QLLRDNLTLW TADNAGEEGG 240
EAPEEPQS 248

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologSFN528453Q0VC36Bos taurusPredictionMore>>
1:1 orthologSFN487351F1PQ93Canis lupus familiarisPredictionMore>>
1:1 orthologSFN102190744A0A452DME8Capra hircusPredictionMore>>
1:1 orthologSFN100057082F7CIM1Equus caballusPredictionMore>>
1:1 orthologSFN2810P31947Homo sapiensPredictionMore>>
1:1 orthologSfn55948O70456CPOE14.5Mus musculusPublicationMore>>
1:1 orthologSFN737412H2RC87Pan troglodytesPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005829 cytosol
GO:0005634 nucleus
GO:0042802 identical protein binding
GO:0051219 phosphoprotein binding
GO:0019901 protein kinase binding
GO:0061436 establishment of skin barrier
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0031424 keratinization
GO:0003334 keratinocyte development
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0010839 negative regulation of keratinocyte proliferation
GO:0030307 positive regulation of cell growth
GO:0045606 positive regulation of epidermal cell differentiation
GO:0046827 positive regulation of protein export from nucleus
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0010482 regulation of epidermal cell division
GO:0001836 release of cytochrome c from mitochondria

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0175 Coiled coil
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR000308 14-3-3
IPR023409 14-3-3_CS
IPR036815 14-3-3_dom_sf
IPR023410 14-3-3_domain
IPR037435 14-3-3_sigma

PROSITE

PROSITE ID PROSITE Term
PS00796 1433_1
PS00797 1433_2

Pfam

Pfam ID Pfam Term
PF00244 14-3-3