| Tag | Content |
|---|---|
| Uniprot ID | O70456; Q3TEZ1; |
| Entrez ID | 55948 |
| Genbank protein ID | BAE41107.1; EDL30056.1; BAE27209.1; AAC14344.1; |
| Genbank nucleotide ID | NM_018754.2 |
| Ensembl protein ID | ENSMUSP00000050374 |
| Ensembl nucleotide ID | ENSMUSG00000047281 |
| Gene name | 14-3-3 protein sigma |
| Gene symbol | Sfn |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | E14.5 |
| Data sources | Manually collected |
| Reference | 479550; 6643653; 17041603; 24075906; |
| Functional description | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53. |
| Sequence | MERASLIQKA KLAEQAERYE DMAAFMKSAV EKGEELSCEE RNLLSVAYKN VVGGQRAAWR 60 VLSSIEQKSN EEGSEEKGPE VKEYREKVET ELRGVCDTVL GLLDSHLIKG AGDAESRVFY 120 LKMKGDYYRY LAEVATGDDK KRIIDSARSA YQEAMDISKK EMPPTNPIRL GLALNFSVFH 180 YEIANSPEEA ISLAKTTFDE AMADLHTLSE DSYKDSTLIM QLLRDNLTLW TADSAGEEGG 240 EAPEEPQS 248 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SFN | 528453 | Q0VC36 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | SFN | 487351 | F1PQ93 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | SFN | 102190744 | A0A452DME8 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SFN | 100057082 | F7CIM1 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | SFN | 2810 | P31947 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Sfn | 55948 | O70456 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | SFN | 737412 | H2RC87 | Pan troglodytes | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005515 | protein binding | IPI |
| GO:0019901 | protein kinase binding | IDA |
| GO:0019904 | protein domain specific binding | IEA |
| GO:0042802 | identical protein binding | ISO |
| GO:0051219 | phosphoprotein binding | IPI |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity | IDA |
| GO:0001836 | release of cytochrome c from mitochondria | ISO |
| GO:0003334 | keratinocyte development | IGI |
| GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage | ISO |
| GO:0010482 | regulation of epidermal cell division | IMP |
| GO:0010839 | negative regulation of keratinocyte proliferation | IGI |
| GO:0030216 | keratinocyte differentiation | IMP |
| GO:0030307 | positive regulation of cell growth | IDA |
| GO:0031424 | keratinization | IMP |
| GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | ISO |
| GO:0043588 | skin development | IMP |
| GO:0043588 | skin development | IGI |
| GO:0045606 | positive regulation of epidermal cell differentiation | IMP |
| GO:0046827 | positive regulation of protein export from nucleus | IDA |
| GO:0051726 | regulation of cell cycle | IDA |
| GO:0061436 | establishment of skin barrier | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005576 | extracellular region | IEA |
| GO:0005634 | nucleus | IDA |
| GO:0005737 | cytoplasm | IDA |
| GO:0005829 | cytosol | ISO |
| GO:0005829 | cytosol | TAS |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-109581 | Apoptosis | IEA |
| R-MMU-109606 | Intrinsic Pathway for Apoptosis | IEA |
| R-MMU-111447 | Activation of BAD and translocation to mitochondria | IEA |
| R-MMU-114452 | Activation of BH3-only proteins | IEA |
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-1640170 | Cell Cycle | IEA |
| R-MMU-194315 | Signaling by Rho GTPases | IEA |
| R-MMU-195258 | RHO GTPase Effectors | IEA |
| R-MMU-212436 | Generic Transcription Pathway | IEA |
| R-MMU-3700989 | Transcriptional Regulation by TP53 | IEA |
| R-MMU-5357801 | Programmed Cell Death | IEA |
| R-MMU-5625740 | RHO GTPases activate PKNs | IEA |
| R-MMU-5628897 | TP53 Regulates Metabolic Genes | IEA |
| R-MMU-6791312 | TP53 Regulates Transcription of Cell Cycle Genes | IEA |
| R-MMU-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest | IEA |
| R-MMU-69473 | G2/M DNA damage checkpoint | IEA |
| R-MMU-69481 | G2/M Checkpoints | IEA |
| R-MMU-69620 | Cell Cycle Checkpoints | IEA |
| R-MMU-73857 | RNA Polymerase II Transcription | IEA |
| R-MMU-74160 | Gene expression (Transcription) | IEA |
| R-MMU-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | IEA |
| R-MMU-9614085 | FOXO-mediated transcription | IEA |
| R-MMU-9614399 | Regulation of localization of FOXO transcription factors | IEA |
| Pfam ID | Pfam Term |
|---|---|
| PF00244 | 14-3-3 |