| Tag | Content |
|---|---|
| Uniprot ID | Q0VC36 |
| Entrez ID | 528453 |
| Genbank protein ID | AAI20374.1 |
| Genbank nucleotide ID | NM_001075912.1 |
| Ensembl protein ID | ENSBTAP00000012154 |
| Ensembl nucleotide ID | ENSBTAG00000009223 |
| Gene name | 14-3-3 protein sigma |
| Gene symbol | SFN |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (By similarity). |
| Sequence | MERASLIQKA KLAEQAERYE DMAAFMKSAV EKGEELSCEE RNLLSVAYKN VVGGQRAAWR 60 VLSSIEQKSN EESSEEKGPE VQEYREKVET ELRGVCDTVL GLLDTHLIKE AGDAESRVFY 120 LKMKGDYYRY LAEVATGDDK KRIIDSARSA YQEAMDISKK EMPPTNPIRL GLALNFSVFH 180 YEIANSPEEA ISLAKTTFDE AMADLHTLSE DSYKDSTLIM QLLRDNLTLW TADNAGEEGG 240 EAPEEPQS 248 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SFN | 528453 | Q0VC36 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | SFN | 487351 | F1PQ93 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | SFN | 102190744 | A0A452DME8 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SFN | 100057082 | F7CIM1 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | SFN | 2810 | P31947 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Sfn | 55948 | O70456 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | SFN | 737412 | H2RC87 | Pan troglodytes | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005829 | cytosol |
| GO:0005576 | extracellular region |
| GO:0005634 | nucleus |
| GO:0042802 | identical protein binding |
| GO:0051219 | phosphoprotein binding |
| GO:0019901 | protein kinase binding |
| GO:0061436 | establishment of skin barrier |
| GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage |
| GO:0031424 | keratinization |
| GO:0003334 | keratinocyte development |
| GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| GO:0010839 | negative regulation of keratinocyte proliferation |
| GO:0030307 | positive regulation of cell growth |
| GO:0045606 | positive regulation of epidermal cell differentiation |
| GO:0046827 | positive regulation of protein export from nucleus |
| GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity |
| GO:0010482 | regulation of epidermal cell division |
| GO:0001836 | release of cytochrome c from mitochondria |
| Pfam ID | Pfam Term |
|---|---|
| PF00244 | 14-3-3 |