| Tag | Content |
|---|---|
| Uniprot ID | F1QKG5 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSDARP00000136120; ENSDARP00000138336; |
| Ensembl nucleotide ID | ENSDARG00000103226 |
| Gene name | 7-dehydrocholesterol reductase |
| Gene symbol | dhcr7 |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MMASDRVRKR HKGSANGAQT VEKEPSKEPA QWGRAWEVDW FSLSGVILLL CFAPFLVFFF 60 IMACDQYQCS ISHPLLDLYN GDATLFTIWN RAPSFTWAAA KIYAIWVTFQ VVLYMCVPDF 120 LHKILPGYVG GVQDGARTPA GLINKYEVNG LQCWLITHVL WVLNAQHFHW FSPTIIIDNW 180 IPLLWCTNIL GYAVSTFAFI KAYLFPTNPE DCKFTGNMFY NYMMGIEFNP RIGKWFDFKL 240 FFNGRPGIVA WTLINLSYAA KQQELYGYVT NSMILVNVLQ AVYVVDFFWN EAWYLKTIDI 300 CHDHFGWYLG WGDCVWLPFL YTLQGLYLVY NPIQLSTPHA AGVLILGLVG YYIFRVTNHQ 360 KDLFRRTEGN CSIWGKKPTF IECSYRSADG AIHKSKLMTS GFWGVARHMN YTGDLMGSLA 420 YCLACGGNHL LPYFYIVYMT ILLVHRCIRD EHRCSNKYGK DWERYTAAVS YRLLPNIF 478 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | DHCR7 | 483675 | E2RNQ5 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | DHCR7 | A0A452EN40 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | DHCR7 | F6TQP5 | Equus caballus | Prediction | More>> | |||
| 1:1 ortholog | DHCR7 | 1717 | Q9UBM7 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Dhcr7 | 13360 | O88455 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | DHCR7 | 451393 | H2R2E7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | DHCR7 | I3LKI5 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Dhcr7 | 64191 | Q9Z2Z8 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | dhcr7 | F1QKG5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016021 | integral component of membrane |
| GO:0016628 | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor |
| GO:0006695 | cholesterol biosynthetic process |
| Keyword ID | Keyword Term |
|---|---|
| KW-0152 | Cholesterol biosynthesis |
| KW-0153 | Cholesterol metabolism |
| KW-0444 | Lipid biosynthesis |
| KW-0443 | Lipid metabolism |
| KW-0472 | Membrane |
| KW-0560 | Oxidoreductase |
| KW-1185 | Reference proteome |
| KW-0752 | Steroid biosynthesis |
| KW-0753 | Steroid metabolism |
| KW-0756 | Sterol biosynthesis |
| KW-1207 | Sterol metabolism |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| Pfam ID | Pfam Term |
|---|---|
| PF01222 | ERG4_ERG24 |