| Tag | Content |
|---|---|
| Uniprot ID | Q9Z2Z8 |
| Entrez ID | 64191 |
| Genbank protein ID | AAH81688.1; AAD31383.1; AAK69490.1; BAA34306.1; AAM45144.1; |
| Genbank nucleotide ID | XM_008760173.2; XM_006230893.3; XM_008760172.2; NM_022389.2; XM_006230892.3; XM_006230894.3; |
| Ensembl protein ID | ENSRNOP00000071939; ENSRNOP00000028194; |
| Ensembl nucleotide ID | ENSRNOG00000020776 |
| Gene name | 7-dehydrocholesterol reductase |
| Gene symbol | Dhcr7 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC). |
| Sequence | MASKSQHNAS KAKNHNVKAE SQGQWGRAWE VDWFSLVSVI FLLLFAPFIV YYFIMACDQY 60 SCSLTAPILD VATGRASLAD IWAKTPPVTA KAAQLYALWV SFQVLLYSWL PDFCHRFLPG 120 YVGGVQEGAI TPAGIVNKYE VNGLQAWLIT HFLWFVNAYL LSWFSPTIIF DNWIPLLWCA 180 NILGYAVSTF AMIKGYLFPT SAEDCKFTGN FFYNYMMGIE FNPRIGKWFD FKLFFNGRPG 240 IVAWTLINLS FAAKQQELYG HVTNSMILVN VLQAIYVLDF FWNETWYLKT IDICHDHFGW 300 YLGWGDCVWL PYLYTLQGLY LVYHPVQLST PNALGVLLLG LVGYYIFRMT NHQKDLFRRT 360 DGHCLIWGKK PKAIECSYTS ADGLKHRSKL LVSGFWGVAR HFNYTGDLMG SLAYCLACGG 420 GHLLPYFYII YMTILLTHRC LRDEHRCANK YGRDWERYVA AVPYRLLPGI F 471 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | DHCR7 | 483675 | E2RNQ5 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | DHCR7 | A0A452EN40 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | DHCR7 | F6TQP5 | Equus caballus | Prediction | More>> | |||
| 1:1 ortholog | DHCR7 | 1717 | Q9UBM7 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Dhcr7 | 13360 | O88455 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | DHCR7 | 451393 | H2R2E7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | DHCR7 | I3LKI5 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Dhcr7 | 64191 | Q9Z2Z8 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | dhcr7 | F1QKG5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005829 | cytosol |
| GO:0030176 | integral component of endoplasmic reticulum membrane |
| GO:0043231 | intracellular membrane-bounded organelle |
| GO:0005640 | nuclear outer membrane |
| GO:0047598 | 7-dehydrocholesterol reductase activity |
| GO:0050661 | NADP binding |
| GO:0016627 | oxidoreductase activity, acting on the CH-CH group of donors |
| GO:0009918 | sterol delta7 reductase activity |
| GO:0001568 | blood vessel development |
| GO:0016132 | brassinosteroid biosynthetic process |
| GO:0030154 | cell differentiation |
| GO:0006695 | cholesterol biosynthetic process |
| GO:0030324 | lung development |
| GO:0035264 | multicellular organism growth |
| GO:0009791 | post-embryonic development |
| GO:0042127 | regulation of cell population proliferation |
| GO:0045540 | regulation of cholesterol biosynthetic process |
| GO:0016126 | sterol biosynthetic process |
| Keyword ID | Keyword Term |
|---|---|
| KW-0152 | Cholesterol biosynthesis |
| KW-0153 | Cholesterol metabolism |
| KW-0256 | Endoplasmic reticulum |
| KW-0444 | Lipid biosynthesis |
| KW-0443 | Lipid metabolism |
| KW-0472 | Membrane |
| KW-0521 | NADP |
| KW-0560 | Oxidoreductase |
| KW-1185 | Reference proteome |
| KW-0752 | Steroid biosynthesis |
| KW-0753 | Steroid metabolism |
| KW-0756 | Sterol biosynthesis |
| KW-1207 | Sterol metabolism |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| Pfam ID | Pfam Term |
|---|---|
| PF01222 | ERG4_ERG24 |