Gene: glceb

Basic information

Tag Content
Uniprot ID F1QR43; B3DID7; Q6TS32;
Entrez ID 100007670
Genbank protein ID AAQ90467.1; AAI63091.1; AAI63093.1;
Genbank nucleotide ID NM_212849.1; XM_005168839.2;
Ensembl protein ID ENSDARP00000151285; ENSDARP00000090760;
Ensembl nucleotide ID ENSDARG00000068981
Gene name D-glucuronyl C5-epimerase B
Gene symbol glceb
Organism Danio rerio
NCBI taxa ID 7955
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains (PubMed:16156897, PubMed:25568314). Plays a role in dorso-ventral axis specification during early development, together with glcea, where it may potentiate signaling via the BMP pathway (PubMed:16156897).
Sequence
MMRCLAARVH YKTLIVICAL LSLLTVLLWN KCTSEKALRF LPRHPQPPPS PKIDSHPQQP 60
QPPEPPPVVG GVRYEEIDCL INDDATIKGR REGSEVYMPF SWMEKYFEVY GKVVQYDGYD 120
RFEFSHSYSK VYAQREQYHP NGVFMSFEGY NVEVRDRVKC ISGVEGVPLS TQWGPQGYFY 180
AIQIAQYGLS HYSKNLTERP PHVEVYDTAE ERDSRSSAWT VPKGCSLTRV YDKTRATSVR 240
QFSAPENSEG VSLPLGNTKD FIISFDLKFT SNGSVSVILE TTEKGPPFVI HYVTTTQLIL 300
LKDRDITYGI GPRTTWTTVT RDLLTDLRKG IGLSNTKAVK ATKTMPRRVV KLVVHGTGTI 360
DNITISTTSH MAAFYAASDW LVRNQDERGG WPIMVTRKLG EGFRALEPGW YSAMAQGQAM 420
STLVRAYLMT KDDTYLKAAL RATGPFKLPS EQHGVKAVFM NKYDWYEEYP TIPSSFVLNG 480
FIYSLIGLFD LAQTAGEKLG RDAGQLYSKG MESLKVMLPL YDTGSGTIYD LRHFILGTAP 540
NLARWDYHTT HINQLQLLGT IDNSPIFRDS VKRWKSYLKG GRAKHN 586

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologGLCE281195O18756Bos taurusPredictionMore>>
1:1 orthologGLCE102172900A0A452EMT4Capra hircusPredictionMore>>
1:1 orthologGLCEF7CXB5Equus caballusPredictionMore>>
1:1 orthologGLCE26035O94923Homo sapiensPredictionMore>>
1:1 orthologGlce93683Q9EPS3CPOE14.5Mus musculusPublicationMore>>
1:1 orthologGLCE453542H2Q9P8Pan troglodytesPredictionMore>>
1:1 orthologGLCE100154444F1SIU0Sus scrofaPredictionMore>>
1:1 orthologGlce363073D3ZIK0Rattus norvegicusPredictionMore>>
1:1 orthologglceb100007670F1QR43Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005794 Golgi apparatus
GO:0000139 Golgi membrane
GO:0016021 integral component of membrane
GO:0047464 heparosan-N-sulfate-glucuronate 5-epimerase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0015012 heparan sulfate proteoglycan biosynthetic process
GO:0030210 heparin biosynthetic process

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0002 3D-structure
KW-0106 Calcium
KW-0333 Golgi apparatus
KW-0413 Isomerase
KW-0472 Membrane
KW-0479 Metal-binding
KW-1185 Reference proteome
KW-0735 Signal-anchor
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR010598 C5-epim_C
IPR039721 C5-epimerase

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF06662 C5-epim_C