| Tag | Content |
|---|---|
| Uniprot ID | O18756 |
| Entrez ID | 281195 |
| Genbank protein ID | AAB72083.2 |
| Genbank nucleotide ID | NM_174070.2; XM_005211251.3; XM_005211252.3; |
| Ensembl protein ID | ENSBTAP00000001844 |
| Ensembl nucleotide ID | ENSBTAG00000001405 |
| Gene name | D-glucuronyl C5-epimerase |
| Gene symbol | GLCE |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins. |
| Sequence | MRCLAARVNY KTLIIICALF TLVTVLLWNK CSSDKAIQVP RHLSSGFRVD ALEKKAAASE 60 SNNYVNHMAK QSEEAFPQEQ QKAPPVVGGF NNNGGGRVLG LKYEEIDCLI NDEHTIKGRR 120 EGNEVFLPFT WVEKYFDVYG KVVQYDGYDR FEFSHSYSKV YAQRAPYHPD GVFMSFEGYN 180 VEVRDRVKCI SGVEGVPLST QWGPQGYFYP IQIAQYGLSH YSKNLTEKPP HIEVYETAED 240 RDKNSKPNDW TVPKGCFMAS VADKSRFTNV KQFIAPETSE GVSLQLGNTK DFIISFDLKF 300 LTNGSVSVVL ETTEKNQLFT VHYVSNTQLI AFKERDIYYG IGPRTSWSTV TRDLVTDLRK 360 GVGLSNTKAV KPTRIMPKKV VRLIAKGKGF LDNITISTTA HMAAFFAASD WLVRNQDEKG 420 GWPIMVTRKL GEGFKSLEPG WYSAMAQGQA ISTLVRAYLL TKDHIFLNSA LRATAPYKFL 480 SEQHGVKAVF MNKHDWYEEY PTTPSSFVLN GFMYSLIGLY DLKETAGEKL GKEARSLYER 540 GMESLKAMLP LYDTGSGTIY DLRHFMLGIA PNLARWDYHT THINQLQLLS TIDESPIFKE 600 FVKRWKSYLK GSRAKHN 617 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | GLCE | 281195 | O18756 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | GLCE | 102172900 | A0A452EMT4 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | GLCE | F7CXB5 | Equus caballus | Prediction | More>> | |||
| 1:1 ortholog | GLCE | 26035 | O94923 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Glce | 93683 | Q9EPS3 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | GLCE | 453542 | H2Q9P8 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | GLCE | 100154444 | F1SIU0 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Glce | 363073 | D3ZIK0 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | glceb | 100007670 | F1QR43 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005794 | Golgi apparatus |
| GO:0000139 | Golgi membrane |
| GO:0016021 | integral component of membrane |
| GO:0005509 | calcium ion binding |
| GO:0047464 | heparosan-N-sulfate-glucuronate 5-epimerase activity |
| GO:0042803 | protein homodimerization activity |
| GO:0016857 | racemase and epimerase activity, acting on carbohydrates and derivatives |
| GO:0015012 | heparan sulfate proteoglycan biosynthetic process |
| GO:0030210 | heparin biosynthetic process |
| Pfam ID | Pfam Term |
|---|---|
| PF06662 | C5-epim_C |